ArticleFrontiers in aging neuroscience2018
Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer's Disease.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Cognitive reserve and effects of air pollution mixture on cognitive function in dementia-free adults.Psychological medicine · 2026Article
- Neural compensation in persons with HIV and marijuana use: Insights from a reorganized DMN.Network neuroscience (Cambridge, Mass.) · 2026Article
- Bridging cognitive reserve and cerebellar networks: counteracting brain damage in patients with Alzheimer's disease at different clinical stages.Frontiers in cellular neuroscience · 2026Article
- Mechanisms and Impact of Cognitive Reserve in Normal Aging and Alzheimer's Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Neuronal Mechanisms of Reading Informational Texts in People with Different Levels of Mental Resilience.Brain sciences · 2024Article
- Cognitive resilience/reserve: Myth or reality? A review of definitions and measurement methods.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Mechanisms and Functions of the Cerebral-Cognitive Reserve in Patients with Alzheimer's Disease: A Narrative Review.Consortium psychiatricum · 2024Review
- Resting-state global brain activity affects early β-amyloid accumulation in default mode network.Nature communications · 2023Article
- The rising role of cognitive reserve and associated compensatory brain networks in spinocerebellar ataxia type 2.Journal of neurology · 2023Article
- Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note.Journal of cardiovascular development and disease · 2023Article
- Education reduces cognitive dysfunction in Alzheimer's disease by changing regional cerebral perfusion: An in-vivo arterial spin labeling study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Machine Learning Decomposition of the Anatomy of Neuropsychological Deficit in Alzheimer's Disease and Mild Cognitive Impairment.Frontiers in aging neuroscience · 2022Article
- State and Trait Anxiety Share Common Network Topological Mechanisms of Human Brain.Frontiers in neuroinformatics · 2022Article
- Common genetic variation is associated with longitudinal decline and network features in behavioral variant frontotemporal degeneration.Neurobiology of aging · 2021Article
- Association of Lifestyle Activities with Functional Brain Connectivity and Relationship to Cognitive Decline among Older Adults.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Microglia and modifiable life factors: Potential contributions to cognitive resilience in aging.Behavioural brain research · 2021Review
- Neuroimaging Research on Dementia in Brazil in the Last Decade: Scientometric Analysis, Challenges, and Peculiarities.Frontiers in neurology · 2021Review
- Aβ misfolding in blood plasma measured by immuno-infrared-sensor as an age-independent risk marker of Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Life-Course Pathways to Cognitive Aging: The Significance of Intellectual Stimulation in the Form of Education and Occupation for Public Policy and Prevention Plans.Frontiers in psychiatry · 2021Article
- Controlling Brain State Prior to Stimulation of Parietal Cortex Prevents Deterioration of Sustained Attention.Cerebral cortex communications · 2020Article
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Authors and funding
12 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is the most common form of dementia, with no means of cure or prevention. The presence of abnormal disease-related proteins in the population is, in turn, much more common than the incidence of dementia. In this context, the cognitive reserve (CR) hypothesis has been proposed to explain the discontinuity between pathophysiological and clinical expression of AD, suggesting that CR mitigates the effects of pathology on clinical expression and cognition. fMRI studies of the human connectome have recently reported that AD patients present diminished functional efficiency in resting-state networks, leading to a loss in information flow and cognitive processing. No study has investigated, however, whether CR modifies the effects of the pathology in functional network efficiency in AD patients. We analyzed the relationship between CR, pathophysiology and network efficiency, and whether CR modifies the relationship between them. Fourteen mild AD, 28 amnestic mild cognitive impairment (aMCI) due to AD, and 28 controls were enrolled. We used education to measure CR, cerebrospinal fluid (CSF) biomarkers to evaluate pathophysiology, and graph metrics to measure network efficiency. We found no relationship between CR and CSF biomarkers; CR was related to higher network efficiency in all groups; and abnormal levels of CSF protein biomarkers were related to more efficient networks in the AD group. Education modified the effects of tau-related pathology in the aMCI and mild AD groups. Although higher CR might not protect individuals from developing AD pathophysiology, AD patients with higher CR are better able to cope with the effects of pathology-presenting more efficient networks despite pathology burden. The present study highlights that interventions focusing on cognitive stimulation might be useful to slow age-related cognitive decline or dementia and lengthen healthy aging.
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