ArticleScientific reports2018
Assessment of cerebral autoregulation using continuous-wave near-infrared spectroscopy during squat-stand maneuvers in subjects with symptoms of orthostatic intolerance.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Predicting outcomes in patients with sepsis-associated encephalopathy using prefrontal functional connectivity analysis.Scientific reports · 2025Article
- Cerebral Haemodynamic Assessment Following Sport-related Concussion (Mild Traumatic Brain Injury) in Youth and Amateur Rugby Union Players.Sports medicine - open · 2025Article
- Cerebral Blood Flow in Orthostatic Intolerance.Journal of the American Heart Association · 2025Review
- Article
- Home-based monitoring of cerebral oxygenation in response to postural changes using near-infrared spectroscopy.GeroScience · 2024Article
- Effect of Positional Changes on Cerebral Perfusion in Parkinson's Disease Patients With Orthostatic Hypotension.Journal of movement disorders · 2024Article
- Investigating the relationship between CSAT scores and prefrontal fNIRS signals during cognitive tasks using a quantum annealing algorithm.Scientific reports · 2024Article
- Increased brain microvascular hemoglobin concentrations in children with cerebral malaria.Science translational medicine · 2023Article
- Change in activity patterns in the prefrontal cortex in different phases during the dual-task walking in older adults.Journal of neuroengineering and rehabilitation · 2023Article
- Cerebral Oxygenation Responses to Standing in Young Patients with Vasovagal Syncope.Journal of clinical medicine · 2023Article
- The different contributions of the eight prefrontal cortex subregions to reactive responses after unpredictable slip perturbations and vibrotactile cueing.Frontiers in human neuroscience · 2023Article
- Efficacy of smartphone application-based multi-domain cognitive training in older adults without dementia.Frontiers in aging neuroscience · 2023Article
- Article
- Early assessment of acute ischemic stroke in rabbits based on multi-parameter near-field coupling sensing.Biomedical engineering online · 2022Article
- Diagnostic Features and Potential Applications of PPG Signal in Healthcare: A Systematic Review.Healthcare (Basel, Switzerland) · 2022Review
- Article
- Frontal lobe hemodynamics detected by functional near-infrared spectroscopy during head-up tilt table tests in patients with electrical burns.Frontiers in human neuroscience · 2022Article
- Prefrontal fNIRS-based clinical data analysis of brain functions in individuals abusing different types of drugs.Journal of biomedical semantics · 2021Article
- Cerebral autoregulation assessed by near-infrared spectroscopy: validation using transcranial Doppler in patients with controlled hypertension, cognitive impairment and controls.European journal of applied physiology · 2021Article
- The slope of cerebral oxyhemoglobin oscillation is associated with vascular reserve capacity in large artery steno-occlusion.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Orthostatic lightheadedness in healthy young adults often leads to syncope in severe cases. One suggested underlying mechanism of orthostatic lightheadedness is a drop in transient blood pressure (BP); however, a decrease in BP does not always lead to a drop in cerebral blood flow (CBF) due to cerebral autoregulation (CA). We present a direct assessment method of CA using a multichannel continuous-wave near-infrared spectroscopy (CW-NIRS) device that measures the temporal changes in oxy- and deoxy-hemoglobin concentrations in the prefrontal cortex. Twenty healthy young adults were recruited. During the experiment, continuous beat-to-beat BP and heart rate were simultaneously measured during repetitive squat-stand maneuvers. We introduce a new metric termed 'time-derivative hemodynamic model (DHbT)', which is the time-derivative of total-hemoglobin concentration change that reflects the changes of cerebral blood volume and CBF. Although the absolute levels and the variations of systolic and diastolic BPs and mean arterial pressure showed no significant difference between the two groups, the proposed model showed a distinct difference in slope variation and response time of DHbT between the subjects with frequent symptom of orthostatic intolerance and the healthy control subjects. Thus, these results clearly demonstrate the feasibility of using CW-NIRS devices as a CA performance assessment tool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.