ReviewNature2018
Facing up to the global challenges of ageing.
Review in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 811 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Secure And Focused Primary Care for Older pEople (SAFE) - A Proactive Trial
Evaluation of the Consumption of Lupins in Brine on Metabolic Markers in Healthy Individuals
Seeing Through Their Eyes - Towards Defining Visual Frailty in Ageing
Effect of Diverse Training Programs on Prevention of Sarcopenia in Postmenopausal Women
Physical Activity and Disability Prevention in Postmenopausal Women
Who cites it
811 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,420 citations in OpenAlex.
- Association between overweight/obesity and oral health in adults aged 55 and older: a systematic review and meta-analysis.GeroScience · 2026Pooled it
- Development and content evaluation of a multidimensional coping model-based health education manual for dementia care support.Frontiers in public health · 2026Pooled it
- Medication experience of aged patients and their family caregivers during transitions of care: a qualitative meta-synthesis.International journal of qualitative studies on health and well-being · 2025Pooled it
- Diagnostic accuracy of history taking, physical examination, and auxiliary examination for thumb osteoarthritis: a systematic review.Annals of medicine · 2025Pooled it
- Effects of one avocado a day for six months on cognitive performance in overweight adults: A randomized controlled trial.The journal of nutrition, health & aging · 2026Trial
- Post-Intubation Hypotension After Titrated Induction with Ciprofol versus Propofol in Older Adults Undergoing Non-Cardiac Surgery: A Randomized Controlled Trial.Clinical interventions in aging · 2026Trial
- Trial
- LncRNA Gm44981 modulates EZH2-H3K27me3-p21 axis to suppress mesangial cell senescence and kidney aging.Renal failure · 2026Article
- The endocannabinoid system and the ageing brain.Nature reviews. Neuroscience · 2026Review
- Multi-modality profiling identifies Neisseria flavescens as a central geroprotective oral commensal in humans.Nature aging · 2026Article
- Article
- Erigeron breviscapus alleviates senescence via AMPK-SIRT1 signaling by modulating FOXO3a-mediated antioxidant defense and p53-dependent apoptosis.Biogerontology · 2026Article
- Phenotypic age metrics for risk stratification of chronic disease burden and all-cause mortality in adults.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Article
- Mitochondrial homeodynamics in ageing: mechanisms, resilience, and interventions.Biogerontology · 2026Review
- Evolutionary genetics of ageing.Nature reviews. Genetics · 2026Review
- Structural decomposition enables multi-omics dissection of common and organ-specific aging.Science China. Life sciences · 2026Article
- An epigenetic clock for chronological age estimation in East Asian populations.NAR genomics and bioinformatics · 2026Article
- Aging regulation by gut microbiota: molecular insights from Caenorhabditis elegans.Biogerontology · 2026Review
- Geroprotective Effects of Drugs Modulating Metabolic Pathways: Perspectives of Pharmacology in Anti-Aging Therapy.International journal of molecular sciences · 2026Review
751 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Longer human lives have led to a global burden of late-life disease. However, some older people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake and obesity, can help to maintain healthspan. Altered gut microbiota, removal of senescent cells, blood factors obtained from young individuals and drugs can all improve late-life health in animals. Application to humans will require better biomarkers of disease risk and responses to interventions, closer alignment of work in animals and humans, and increased use of electronic health records, biobank resources and cohort studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.