Evidence map›Paper›PMID 30185939›Full record

ArticleJournal of exposure science & environmental epidemiology2019

The association between cumulative cadmium intake and osteoporosis and risk of fracture in a Chinese population.

Xiao Chen, Zhongqiu Wang, Guoying Zhu, Gunnar F Nordberg, Taiyi Jin, Xiaoqiang Ding

Abstract read
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In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  3. Exposure to heavy metals and the risk of osteopenia or osteoporosis: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Xiao ChenDepartment of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 # hanzhong Road, Nanjing, 210029, China.
Zhongqiu WangDepartment of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 # hanzhong Road, Nanjing, 210029, China.
Guoying ZhuInstitute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai, 200032, China. zhugy@shmu.edu.cn.
Gunnar F NordbergDepartment of Public Health and Clinical Medicine, Umeå University, 901 87, Umeå, Sweden.
Taiyi JinDepartment of Occupational Medicine, School of Public Health, Fudan University, 150 Dongan Road, Shanghai, 200032, China.
Xiaoqiang DingDepartment of Nephrology, Zhongshan Hospital Fudan University, Shanghai Institute of Kidney Disease and Dialysis, Shanghai, 200032, China. ding_xiaoqiang@zs-hospital.sh.cn.
Fudan University · CNNanjing University of Chinese Medicine · CNThe First Affiliated Hospital, Sun Yat-sen University · CNUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone is one of the target organs for cadmium toxicity. However, few studies have shown the association between cumulative cadmium intake and prevalence of osteoporosis and bone fracture. In the present study, we evaluated the association between cumulative cadmium intake and osteoporosis and risk of fracture in a Chinese population. A total of 790 subjects (488 women and 302 men) living in a control area and two cadmium-polluted areas were included. The cumulative cadmium intake was estimated by a food survey. The bone mineral density was determined by using single-photon absorptiometry. The cumulative cadmium intakes were 0.48, 2.14, and 11.00 g for men, and 0.42, 2.11, and 11.12 g in women in control, and moderately and heavily polluted areas, respectively. In women, the odds ratios (ORs) of subjects with a cadmium intake between 2.21 and 10.63 g and >10.63 g were 1.30 (95% CI: 0.58-2.94) and 2.36 (95% CI: 1.14-5.16), compared with those with a cadmium intake < 0.58 g after adjusting to the confounders for osteoporosis. The ORs of subjects with a cadmium intake >10.63 g were 2.34 (95% CI: 1.23-4.38) for all of the women and 2.62 (95% CI: 1.02-5.58) in women ≥ 60 years old, compared with those with a cadmium intake <10.63 g after adjusting to the confounders for bone fractures. In men, similar trends were observed, but no statistical significance was found. In addition, those subjects with renal tubular dysfunction showed high risk of bone fracture. Our results indicate that a high level of cumulative cadmium intake is associated with an increased rate of osteoporosis and fractures among women.

Indexed as

AdultAgedBone DensityCadmiumChinaFemaleFractures, BoneHumansMaleMiddle AgedOsteoporosisRisk FactorsCadmiumBoneBone fractureCadmiumCumulative intakeOsteoporosis

Identifiers

PMID30185939
OpenAlexW2891779466

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.