ArticleInternational journal of obesity (2005)2019
Brown adipose tissue in prepubertal children: associations with sex, birthweight, and metabolic profile.
Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Infrared Thermography for Estimating Supraclavicular Skin Temperature and BAT Activity in Humans: A Systematic Review.Obesity (Silver Spring, Md.) · 2019Pooled it
- Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology.Biology of sex differences · 2025Review
- Infrared thermography unveiled the variation of brown adipose tissue thermogenesis among East Asian adults.Physiological reports · 2025Article
- Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study.Scientific reports · 2025Article
- Ependymin-related protein 1 levels are elevated in children with obesity and correlated with metabolic disorders.Pediatric discovery · 2024Article
- Subcutaneous and Visceral Fat: Relation with Brown Adipose Tissue Activation in Women.Sports medicine international open · 2024Article
- Article
- Sex differences in thermoregulation in mammals: Implications for energy homeostasis.Frontiers in endocrinology · 2023Review
- The Sexual Dimorphism of Human Adipose Depots.Biomedicines · 2022Review
- Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.International journal of molecular sciences · 2022Review
- Bone Morphogenetic Protein-8B Levels at Birth and in the First Year of Life: Relation to Metabolic-Endocrine Variables and Brown Adipose Tissue Activity.Frontiers in pediatrics · 2022Article
- Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome.Frontiers in pediatrics · 2022Review
- Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children.The Journal of clinical endocrinology and metabolism · 2021Article
- The relationship between famine exposure during early life and carotid plaque in adulthood.European journal of clinical nutrition · 2021Article
- Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk.Frontiers in endocrinology · 2021Review
- Developmental Programming of Body Composition: Update on Evidence and Mechanisms.Current diabetes reports · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesIndividuals born small-for-gestational age (SGA), especially those who experience postnatal catch-up growth, are at increased risk for developing endocrine-metabolic abnormalities before puberty. In adults, brown adipose tissue (BAT) has been associated with protection against metabolic disorders, such as obesity, type 2 diabetes, and dyslipidaemia. Here, we assessed for the first time whether BAT activation differs between prepubertal children born SGA or appropriate-for-gestational age (AGA). SUBJECTS/
methodsThe study population consisted of 86 prepubertal children [41 AGA and 45 SGA; age (mean ± SEM), 8.5 ± 0.1 years], recruited into two prospective longitudinal studies assessing endocrine-metabolic status and body composition in infancy and childhood. The temperature at the supraclavicular region (SCR) before and after a cold stimulus was measured by infrared thermal imaging, and the area of thermally active SCR (increase after cold challenge, ΔArea
resultsNo differences in BAT activation index, as judged by ΔArea
conclusionsPrepubertal AGA girls had significantly greater BAT activation index as compared to AGA boys; this difference was not observed in SGA subjects. Higher BAT activation associated with a lower amount of visceral fat and with a favorable metabolic profile. Long-term follow-up is needed to determine whether those differences relate to pubertal timing, and to the development of obesity and metabolic disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.