Evidence map›Paper›PMID 30185907›Full record

ArticleNature2018

A fluid-to-solid jamming transition underlies vertebrate body axis elongation.

Alessandro Mongera, Payam Rowghanian, Hannah J Gustafson, Elijah Shelton, David A Kealhofer, Emmet K Carn, Friedhelm Serwane, Adam A Lucio, James Giammona, Otger Campàs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 340 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
340citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

340 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Changes in Tissue Fluidity Predict Tumor Aggressiveness In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Mechanics of compression-driven morphogenesis.Development (Cambridge, England) · 2026
    Review
  12. Article
  13. The role of geometry in morphogenesis.Development (Cambridge, England) · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

280 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alessandro MongeraDepartment of Mechanical Engineering, University of California, Santa Barbara, CA, USA.
Payam RowghanianDepartment of Mechanical Engineering, University of California, Santa Barbara, CA, USA.
Hannah J GustafsonDepartment of Mechanical Engineering, University of California, Santa Barbara, CA, USA.
Elijah SheltonDepartment of Mechanical Engineering, University of California, Santa Barbara, CA, USA.
David A KealhoferDepartment of Physics, University of California, Santa Barbara, CA, USA.
Emmet K CarnDepartment of Mechanical Engineering, University of California, Santa Barbara, CA, USA.
Friedhelm SerwaneDepartment of Mechanical Engineering, University of California, Santa Barbara, CA, USA.
Adam A LucioDepartment of Mechanical Engineering, University of California, Santa Barbara, CA, USA.
James GiammonaCalifornia NanoSystems Institute, University of California, Santa Barbara, CA, USA.
Otger CampàsDepartment of Mechanical Engineering, University of California, Santa Barbara, CA, USA. campas@ucsb.edu.

Funding

Biomechanical mechanisms underlying the formation of the vertebrate body axisR01HD095797 · NICHD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI CAMPAS, OTGER · 2018 to 2023
$1.8M
Biomechanics of gastrulation in zebrafishR21HD084285 · NICHD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI CAMPAS, OTGER · 2015 to 2016
$411k
National Science Foundation CMMI-1562910NICHD NIH HHS R01 HD095797NICHD NIH HHS R21 HD084285
6 · The paper itself

Abstract

Just as in clay moulding or glass blowing, physically sculpting biological structures requires the constituent material to locally flow like a fluid while maintaining overall mechanical integrity like a solid. Disordered soft materials, such as foams, emulsions and colloidal suspensions, switch from fluid-like to solid-like behaviours at a jamming transition

Indexed as

Embryonic DevelopmentModels, BiologicalAnimalsCadherinsMesodermZebrafishCadherins

Identifiers

PMID30185907
PMCPMC6148385

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.