Evidence map›Paper›PMID 30185885›Full record

ArticleScientific reports2018

MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network.

J J Brudvig, J T Cain, R M Sears, G G Schmidt-Grimminger, E S Wittchen, K B Adler, H T Ghashghaei, J M Weimer

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer's Disease?International journal of molecular sciences · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Small GTPases and Their Role in Vascular Disease.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

J J BrudvigPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA.
J T CainPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA.
R M SearsPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA.
G G Schmidt-GrimmingerPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA.
E S WittchenDepartment of Cell Biology & Physiology, University of North Carolina, Chapel Hill, NC, 27599, USA.
K B AdlerMolecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA.
H T GhashghaeiMolecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA.
J M WeimerPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA. Jill.Weimer@sanfordhealth.org.
Sanford Research · USNorth Carolina State University · USUniversity of North Carolina at Chapel Hill · USUniversity of Sioux Falls · USUniversity of South Dakota · US

Funding

Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2M
The Impact of PD-1 Inhibition on Immune-Response to ChemoradiotherapyP20GM103548 · NIGMS · SANFORD RESEARCH/USD · PI MISKIMINS, W KEITH · 2012 to 2020
$20.8M
Novel mechanisms for distal transport in developing and mature neuronsR01NS082283 · NINDS · SANFORD RESEARCH/USD · PI WEIMER, JILL M · 2014 to 2018
$1.9M
Role of ependyma in forebrain homeostasisR01NS098370 · NINDS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI GHASHGHAEI, HOOMAN TROY · 2016 to 2020
$1.6M
NIGMS NIH HHS P20 GM103548NIGMS NIH HHS P20 GM103620NINDS NIH HHS R01 NS082283NINDS NIH HHS R01 NS098370
6 · The paper itself

Abstract

Through the process of neuronal differentiation, newly born neurons change from simple, spherical cells to complex, sprawling cells with many highly branched processes. One of the first stages in this process is neurite initiation, wherein cytoskeletal modifications facilitate membrane protrusion and extension from the cell body. Hundreds of actin modulators and microtubule-binding proteins are known to be involved in this process, but relatively little is known about how upstream regulators bring these complex networks together at discrete locations to produce neurites. Here, we show that Myristoylated alanine-rich C kinase substrate (MARCKS) participates in this process. Marcks

Indexed as

ActinsAnimalscdc42 GTP-Binding ProteinCytoskeletonFemaleMaleMiceMice, Inbred C57BLMicrotubulesMyristoylated Alanine-Rich C Kinase SubstrateNeuritesNeuronsPhosphorylationPrimary Cell CultureProtein BindingPseudopodiaActinscdc42 GTP-Binding ProteinMarcks protein, mouseMyristoylated Alanine-Rich C Kinase Substrate

Identifiers

PMID30185885
PMCPMC6125478
OpenAlexW2889543808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.