Evidence map›Paper›PMID 30185882›Full record

ArticleScientific reports2018

Genetic Determinants of Telomere Length in African American Youth.

Andrew M Zeiger, Marquitta J White, Celeste Eng, Sam S Oh, Jonathan Witonsky, Pagé C Goddard, Maria G Contreras, Jennifer R Elhawary, Donglei Hu, Angel C Y Mak and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 1 country.

Andrew M ZeigerDepartment of Medicine, University of California, San Francisco, CA, USA.
Marquitta J WhiteDepartment of Medicine, University of California, San Francisco, CA, USA. marquitta.white@ucsf.edu.
Celeste EngDepartment of Medicine, University of California, San Francisco, CA, USA.
Sam S OhDepartment of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0002-2815-6037
Jonathan WitonskyDepartment of Medicine, University of California, San Francisco, CA, USA.
Pagé C GoddardDepartment of Medicine, University of California, San Francisco, CA, USA.
Maria G ContrerasDepartment of Medicine, University of California, San Francisco, CA, USA.
Jennifer R ElhawaryDepartment of Medicine, University of California, San Francisco, CA, USA.
Donglei HuDepartment of Medicine, University of California, San Francisco, CA, USA.
Angel C Y MakDepartment of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0002-5372-4198
Eunice Y LeeDepartment of Medicine, University of California, San Francisco, CA, USA.
Kevin L KeysDepartment of Medicine, University of California, San Francisco, CA, USA.
Lesly-Anne SamedyDepartment of Medicine, University of California, San Francisco, CA, USA.
Oona Risse-AdamsDepartment of Medicine, University of California, San Francisco, CA, USA.
Joaquín MagañaDepartment of Medicine, University of California, San Francisco, CA, USA.
Scott HuntsmanDepartment of Medicine, University of California, San Francisco, CA, USA.
Sandra SalazarDepartment of Medicine, University of California, San Francisco, CA, USA.
Adam DavisChildren's Hospital and Research Center Oakland, Oakland, CA, USA.
Kelley MeadeChildren's Hospital and Research Center Oakland, Oakland, CA, USA.
Emerita Brigino-BuenaventuraDepartment of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, CA, USA.
Michael A LeNoirBay Area Pediatrics, Oakland, CA, USA.
Harold J FarberDepartment of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Kirsten Bibbins-DomingoDepartment of Medicine, University of California, San Francisco, CA, USA.
Luisa N BorrellDepartment of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, NY, USA.ORCID 0000-0002-0560-4853
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, CA, USA.
University of California, San Francisco · USBaylor College of Medicine · USCity University of New York · USKaiser Permanente Vallejo Medical Center · USKIPP Bay Area Schools · USUniversity of Massachusetts Lowell · US

Funding

UCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4M
SF BUILD: Enabling Students to Represnt in ScienceUL1GM118985 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$18.2M
UPGRADE OF COMMUNICATIONS INFRASTRUCTURET34GM008574 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI BAYLISS, FRANK T, ESQUERRA, RAYMOND M. · 1996 to 2021
$14.5M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
CLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HIATT, ROBERT A · 2012 to 2016
$6.4M
SF BUILD: Enabling Students to Represent in ScienceTL4GM118986 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2022
$5.4M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
SF BUILD: Enabling Students to Represent in ScienceRL5GM118984 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$5.2M
Transcriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1M
Genes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8M
Genetic Control of Airway Epithelium Gene Expression in Childhood AsthmaticsR01HL128439 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2015 to 2019
$3.1M
NHLBI NIH HHS K01 HL140218NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL141992NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS K12 GM081266NIGMS NIH HHS RL5 GM118984NIGMS NIH HHS T32 GM007546NIGMS NIH HHS T34 GM008574NIGMS NIH HHS TL4 GM118986NIGMS NIH HHS UL1 GM118985NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443Tobacco-Related Disease Research Program (TRDRP) 24RT-0025Tobacco-Related Disease Research Program (TRDRP) 27IR-0030U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) X01HL134589
6 · The paper itself

Abstract

Telomere length (TL) is associated with numerous disease states and is affected by genetic and environmental factors. However, TL has been mostly studied in adult populations of European or Asian ancestry. These studies have identified 34 TL-associated genetic variants recently used as genetic proxies for TL. The generalizability of these associations to pediatric populations and racially diverse populations, specifically of African ancestry, remains unclear. Furthermore, six novel variants associated with TL in a population of European children have been identified but not validated. We measured TL from whole blood samples of 492 healthy African American youth (children and adolescents between 8 and 20 years old) and performed the first genome-wide association study of TL in this population. We were unable to replicate neither the 34 reported genetic associations found in adults nor the six genetic associations found in European children. However, we discovered a novel genome-wide significant association between TL and rs1483898 on chromosome 14. Our results underscore the importance of examining genetic associations with TL in diverse pediatric populations such as African Americans.

Indexed as

AdolescentAsian PeopleBlack or African AmericanChildFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideTelomereTelomere HomeostasisWhite PeopleYoung Adult

Identifiers

PMID30185882
PMCPMC6125592
OpenAlexW2950063191

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.