Evidence map›Paper›PMID 30185873›Full record

ArticleScientific reports2018

Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development.

Atsumi Tsuji-Hosokawa, Kenichi Kashimada, Tomoko Kato, Yuya Ogawa, Risa Nomura, Kei Takasawa, Rowena Lavery, Andrea Coschiera, David Schlessinger, Vincent R Harley and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Sertoli cells as a hub in testicular development and male reproductive.Frontiers in cell and developmental biology · 2025
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Atsumi Tsuji-HosokawaDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan.
Kenichi KashimadaDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan. kkashimada.ped@tmd.ac.jp.ORCID 0000-0003-2505-5932
Tomoko KatoDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, 157-8535, Japan.
Yuya OgawaDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, 157-8535, Japan.
Risa NomuraDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan.
Kei TakasawaDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan.ORCID 0000-0001-6947-4034
Rowena LaveryCenter for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Andrea CoschieraIRP Laboratory of Genetics, NIH Biomedical Research Center National Institute on Aging, Baltimore, 21224 MD, USA.
David SchlessingerIRP Laboratory of Genetics, NIH Biomedical Research Center National Institute on Aging, Baltimore, 21224 MD, USA.
Vincent R HarleyCenter for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.ORCID 0000-0002-2405-1262
Shuji TakadaDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, 157-8535, Japan.
Tomohiro MorioDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan.
Tokyo Medical and Dental University · JPNational Center For Child Health and Development · JPHudson Institute of Medical Research · AUNational Institute on Aging · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptidyl arginine deiminases (PADIs) are enzymes that change the charge of proteins through citrullination. We recently found Padi2 was expressed exclusively in fetal Sertoli cells. In this study, we analyzed the transcriptional regulation of Padi2 and the role of PADI2 in testicular development. We showed SOX9 positively regulated Padi2 transcription and FOXL2 antagonized it in TM3 cells, a model of Sertoli cells. The responsive region to SOX9 and FOXL2 was identified within the Padi2 sequence by reporter assay. In fetal testes from Sox9 knockout (AMH-Cre:Sox9

Indexed as

AnimalsCell LineForkhead Box Protein L2Gene Expression Regulation, DevelopmentalHEK293 CellsHumansMaleMiceMice, Inbred C57BLMice, Inbred DBAProtein-Arginine DeiminasesProtein-Arginine Deiminase Type 2Sertoli CellsSOX9 Transcription FactorTestisForkhead Box Protein L2PADI2 protein, humanPadi2 protein, mouseProtein-Arginine DeiminasesProtein-Arginine Deiminase Type 2SOX9 protein, humanSox9 protein, mouseSOX9 Transcription Factor

Identifiers

PMID30185873
PMCPMC6125343
OpenAlexW2888936689

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.