ArticleScientific reports2018
Strongly Coupled Morphological Features of Aortic Aneurysms Drive Intraluminal Thrombus.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Unsupervised machine learning for identifying morphological phenotypes in abdominal aortic aneurysms using fully automated volume-segmented imaging: a multicentre cohort study.European heart journal. Digital health · 2026Article
- Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study.Bioengineering (Basel, Switzerland) · 2025Article
- Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms.The Journal of clinical investigation · 2022Article
- Association of Aneurysm Tissue Neutrophil Mediator Levels with Intraluminal Thrombus Thickness in Patients with Abdominal Aortic Aneurysm.Biomolecules · 2022Article
- Association of vortical structures and hemodynamic parameters for regional thrombus accumulation in abdominal aortic aneurysms.International journal for numerical methods in biomedical engineering · 2022Article
- The Effects of Geometric Features of Intraluminal Thrombus on the Vessel Wall Oxygen Deprivation.Frontiers in bioengineering and biotechnology · 2022Article
- Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair.Frontiers in physiology · 2022Article
- Intraluminal thrombus: Innocent bystander or factor in abdominal aortic aneurysm pathogenesis?JVS-vascular science · 2021Review
- Analysis of hemodynamic changes from aneurysm inception to large sizes.International journal for numerical methods in biomedical engineering · 2021Article
- Mechanical, structural, and physiologic differences in human elastic and muscular arteries of different ages: Comparison of the descending thoracic aorta to the superficial femoral artery.Acta biomaterialia · 2021Article
- Computational evaluation of an extra-aortic elastic-wrap applied to simulated aging anisotropic human aorta models.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Over 75% of abdominal aortic aneurysms harbor an intraluminal thrombus, and increasing evidence suggests that biologically active thrombus contributes to the natural history of these potentially lethal lesions. Thrombus formation depends on the local hemodynamics, which in turn depends on morphological features of the aneurysm and near vasculature. We previously presented a hemodynamically motivated "thrombus formation potential" that predicts where and when thrombus might form. Herein, we combine detailed studies of the three-dimensional hemodynamics with methods of sparse grid collocation and interpolation via kriging to examine roles of five key morphological features of aneurysms on thrombus formation: lesion diameter, axial position, length, curvature, and renal artery position. Computational simulations suggest that maximum diameter is a key determinant of thrombogenicity, but other morphological features modulate this dependence. More distally located lesions tend to have a higher thrombus formation potential and shorter lesions tend to have a higher potential than longer lesions, given the same aneurysmal dilatation. Finally, movement of vortical structures through the infrarenal aorta and lesion can significantly affect thrombogenicity. Formation of intraluminal thrombus within an evolving abdominal aortic aneurysm thus depends on coupled morphological features, not all intuitive, and computational simulations can be useful for predicting thrombogenesis.
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