ArticleScientific reports2018
Improvement of osteogenesis by a uniform PCL coating on a magnesium screw for biodegradable applications.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Temporal immunomodulation of CD4Science advances · 2026Article
- pH-Responsive mPEG-PLGA/Dexamethasone Coatings for Corrosion Control and Osteo-Immune Modulation of Biodegradable Magnesium.Polymers · 2026Article
- Novel Polycaprolactone Based Coating for Catheters: Sustained Antibiotic Release for Enhanced Infection Prevention.International journal of molecular sciences · 2025Article
- Organic-Inorganic Biocompatible Coatings for Temporary and Permanent Metal Implants.International journal of molecular sciences · 2024Review
- Advances in amelioration of plasma electrolytic oxidation coatings on biodegradable magnesium and alloys.Heliyon · 2024Review
- Amorphous, Carbonated Calcium Phosphate and Biopolymer-Composite-Coated SiNanomaterials (Basel, Switzerland) · 2024Article
- Biodegradable Polymers in Biomedical Applications: A Review-Developments, Perspectives and Future Challenges.International journal of molecular sciences · 2023Review
- Biological Performance of Duplex PEO + CNT/PCL Coating on AZ31B Mg Alloy for Orthopedic and Dental Applications.Journal of functional biomaterials · 2023Article
- Article
- Review
- Functional engineering strategies of 3D printed implants for hard tissue replacement.Regenerative biomaterials · 2023Review
- Performance of PEO/Polymer Coatings on the Biodegradability, Antibacterial Effect and Biocompatibility of Mg-Based Materials.Journal of functional biomaterials · 2022Review
- Electrophoretically Deposited Chitosan/Eudragit E 100/AgNPs Composite Coatings on Titanium Substrate as a Silver Release System.Materials (Basel, Switzerland) · 2021Article
- Biopolymer Coatings for Biomedical Applications.Polymers · 2020Review
- Magnesium-alloy rods reinforced bioglass bone cement composite scaffolds with cortical bone-matching mechanical properties and excellent osteoconductivity for load-bearing bone in vivo regeneration.Scientific reports · 2020Article
- Composite Membranes of Poly(ε-caprolactone) with Bisphosphonate-Loaded Bioactive Glasses for Potential Bone Tissue Engineering Applications.Molecules (Basel, Switzerland) · 2019Article
- A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment.Science translational medicine · 2019Article
- MAPLE-prepared graphene oxide-based coatings for improved orthopedic screws used in knee interventions.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A polymer coating as polycaprolactone (PCL) is applied to improve the initial corrosion resistance of biodegradable magnesium. In addition, plasma electrolytic oxidation (PEO) is performed to increase adhesion between the polymer and the metal. However, when a complex-shaped material such as a screw is implanted in a bone, the surface coatings are locally damaged, and the protective role of the coating is not sufficiently maintained. In this study, the optimal conditions for producing a polymer coating on a screw were determined by varying the concentration of the PCL and the coating cycles, and were examined in vitro and in vivo. Among various the PCL coating conditions of 2∼6 cycles with 5∼7 wt.% concentrations, the 6 wt.% + 4 cycles group was applied uniformly to the screw thread. In the case of the non-uniform PCL layers, oxides and gases were present between the Mg and the PCL layer because internal magnesium corrosion and the layer peel off. The 6 wt.% + 4 cycles group had a high corrosion resistance due to the low wear on the thread. Denser and thicker bone formed around the PCL-coated screw in rat femur. This difference was due to the high corrosion resistance, which provided sufficient time for bone healing and promoting new bone growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.