ArticleScience translational medicine2018
Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.
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Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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0cells of the map it votes in
36citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
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Who cites it
36 citing papers in PubMed, 46 citations in OpenAlex.
- Comparing effects of breathing exercises alone and combined with breathing-stretching exercises on respiratory indices, disease severity and exercise capacity in COPD.Scientific reports · 2025Trial
- Hypercapnia enhances airway smooth muscle contractility via STIM1-dependent Ca2+ signaling.JCI insight · 2026Article
- Hypercapnia Effects on Lung Function.Comprehensive Physiology · 2026Review
- Neuroplastic Effects Induced by Hypercapnic Hypoxia in Rat Focal Ischemic Stroke Are Driven via BDNF and VEGF Signaling.International journal of molecular sciences · 2025Article
- Hypercapnia promotes maladaptive airway and vascular remodeling in mice.The Journal of clinical investigation · 2025Article
- Sensing molecular carbon dioxide: a translational focus for respiratory disease.Physiological reviews · 2025Review
- Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis.International journal of molecular sciences · 2025Review
- Nrf2/HO-1 signaling activation alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis.Journal of cardiothoracic surgery · 2024Article
- A Non-Functional Carbon Dioxide-Mediated Post-Translational Modification on Nucleoside Diphosphate Kinase ofInternational journal of molecular sciences · 2024Article
- Carbon dioxide regulates cholesterol levels through SREBP2.PLoS biology · 2023Article
- Mild and moderate chronic hypercapnia elicit distinct transcriptomic responses of immune function in cardiorespiratory nuclei.Physiological genomics · 2023Article
- Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023Review
- Hypercapnia alters mitochondrial gene expression and acylcarnitine production in monocytes.Immunology and cell biology · 2023Article
- Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells.JCI insight · 2023Article
- Hypercapnia increases ACE2 expression and pseudo-SARS-CoV-2 entry in bronchial epithelial cells by augmenting cellular cholesterol.Frontiers in immunology · 2023Article
- Near atmospheric carbon dioxide activates plant ubiquitin cross-linking.BBA advances · 2023Article
- Ventilatory neural drive in chronically hypercapnic patients with COPD: effects of sleep and nocturnal noninvasive ventilation.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Hypercapnia in COPD: Causes, Consequences, and Therapy.Journal of clinical medicine · 2022Review
- Transcription Factor p300 Regulated miR-451b Weakens the Cigarette Smoke Extract-Induced Cellular Stress by Targeting RhoA/ROCK2 Signaling.Oxidative medicine and cellular longevity · 2022Article
- Editorial: Elevated Carbon Dioxide Sensing and Physiologic Effects.Frontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Masahiko ShigemuraDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-7767-6584
Emilia LecuonaDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA.
Martín AnguloPathophysiology Department, School of Medicine, Universidad de la República, Montevideo, Uruguay.ORCID 0000-0002-3326-5764
Tetsuya HommaDivision of Allergology and Respiratory Medicine, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Diego A RodríguezPulmonology Department, Hospital del Mar, Institut Hospital del Mar d'Investigacions Me`diques, Universitat Pompeu Fabra, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), ISCiii, Barcelona, Spain.
Francisco J Gonzalez-GonzalezDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA.
Lynn C WelchDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-1666-3696
Luciano AmarelleDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA.
Seok-Jo KimDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA.
Naftali KaminskiDepartment of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0001-5917-4601
G R Scott BudingerDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-3114-5208
Julian SolwayDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-0898-8530
Jacob I SznajderDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA. j-sznajder@northwestern.edu.ORCID 0000-0002-2089-4764
Northwestern University · USCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESShowa University · JPUniversidad de la República de Uruguay · UYUniversity of Chicago · USYale University · US
Funding
Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2003 to 2019
$30.8MThe Role of Keratinocytes as Independent ThermosensorsP30AR057216 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PALLER, AMY S · 2009 to 2018
$6.0MThe injurious effects of hypercapnia on the alveolar epitheliumR01HL085534 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2006 to 2018
$4.9MRole and Regulation of Sodium, Potasium ATPase in LungR37HL048129 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2008 to 2017
$4.0MROLE AND REGULATION OF SODIUM, POTASSIUM ATPASE IN LUNGR01HL048129 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 1996 to 2007
$2.7MRole of hypercapnia on the lung airwaysR01HL147070 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2019 to 2022
$1.9MRecruitment of New Faculty to Enhance Research in Lung BiologyP30HL101292 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2009 to 2010
$887kNHLBI NIH HHS P01 HL071643NHLBI NIH HHS P30 HL101292NHLBI NIH HHS R01 HL048129NHLBI NIH HHS R01 HL085534NHLBI NIH HHS R01 HL147070NHLBI NIH HHS R37 HL048129NIAMS NIH HHS P30 AR057216
Abstract
The elevation of carbon dioxide (CO
Indexed as
Muscle ContractionSignal TransductionAcetylcholineAgedAged, 80 and overAirway ResistanceAnimalsCalciumCalpainCarbon DioxideCaspase 7Chronic DiseaseDown-RegulationEnzyme ActivationFemaleHumansAcetylcholineCalciumCalpainCarbon DioxideCaspase 7MEF2 Transcription FactorsMicroRNAsMirn133 microRNA, mouserhoA GTP-Binding Protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.