Evidence map›Paper›PMID 30185628›Full record

ArticleCancer discovery2018

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness.

Bernhard W Renz, Takayuki Tanaka, Masaki Sunagawa, Ryota Takahashi, Zhengyu Jiang, Marina Macchini, Zahra Dantes, Giovanni Valenti, Ruth A White, Moritz A Middelhoff and 15 more

Expression of concernAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 223 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
223citing papers in PubMed, 2 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

223 citing papers in PubMed, 2 syntheses or guidelines pooled it, 310 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Niches in cancer: from primary tumors to metastatic disease.Journal of hematology & oncology · 2026
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  20. Molecular mechanisms and therapeutic targets in lung cancer-nerve crosstalk.Chinese medical journal pulmonary and critical care medicine · 2026
    Review

163 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 5 countries.

Bernhard W Renz *Department of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9574-8051
Takayuki Tanaka *Division of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Masaki Sunagawa *Division of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Ryota Takahashi *Division of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Zhengyu JiangDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Marina MacchiniDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Zahra DantesDepartment of Medicine II, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Giovanni ValentiDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Ruth A WhiteDivision of Oncology, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Moritz A MiddelhoffDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Matthias IlmerDepartment of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9597-1368
Paul E ObersteinPerlmutter Cancer Center, New York University Langone Medical Center, New York, New York.ORCID 0000-0001-5918-6004
Martin K AngeleDepartment of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Huan DengDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Yoku HayakawaDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
C Benedikt WestphalenDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.ORCID 0000-0002-5310-3754
Jens WernerDepartment of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Helen RemottiDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.ORCID 0000-0003-1555-9299
Maximilian ReichertDepartment of Medicine II, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Yagnesh H TailorDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Karan NagarDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.ORCID 0000-0002-6965-4825
Richard A FriedmanBiomedical Informatics Shared Resource of the Herbert Irving Comprehensive Cancer Center and Department of Biomedical Informatics, Columbia University Medical Center, New York, New York.
Alina C IugaDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
Kenneth P OliveDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Timothy C WangDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York. tcw21@columbia.edu.
Columbia University Irving Medical Center · USGerman Cancer Research Center · DETUM Klinikum · DENanchang University · CNNYU Langone Health · USVita-Salute San Raffaele University · IT

Funding

The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2M
Molecular Oncology Training ProgramT32CA203703 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Katherine D Crew, DAWN HERSHMAN · 2016 to 2026
$4.1M
NCI NIH HHS R35 CA210088NCI NIH HHS T32 CA203703
6 · The paper itself

Abstract

In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) has not been defined. Here, we found that subdiaphragmatic vagotomy in LSL-

Indexed as

AnimalsCarcinoma, Pancreatic DuctalCell Transformation, NeoplasticCholinergic AgentsGenes, rasHumansMiceMice, Inbred C57BLMice, Inbred NODMice, KnockoutMice, SCIDNeoplastic Stem CellsPancreatic NeoplasmsReceptor, Muscarinic M1Signal TransductionCholinergic AgentsReceptor, Muscarinic M1

Identifiers

PMID30185628
PMCPMC6214763
OpenAlexW2891570794

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.