Evidence map›Paper›PMID 30185620›Full record

ArticleThe Journal of biological chemistry2018

Dissecting MMP P

Michal Tokmina-Roszyk, Gregg B Fields

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michal Tokmina-RoszykFrom the Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, Florida 33458 and.
Gregg B FieldsFrom the Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, Florida 33458 and fieldsg@fau.edu gfields@scripps.edu.
Florida Atlantic University · US

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Mechanism &Inhibition of Collagenolytic ActivityR01CA098799 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FIELDS, GREGG B · 2003 to 2017
$4.5M
NCI NIH HHS R01 CA098799NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that remodel the extracellular matrix environment and mitigate outside-in signaling. Loss of regulation of MMP activity plays a role in numerous pathological states. In particular, aberrant collagenolysis affects tumor invasion and metastasis, osteoarthritis, and cardiovascular and neurodegenerative diseases. To evaluate the collagen sequence preferences of MMPs, a positional scanning synthetic combinatorial library was synthesized herein and was used to investigate the P

Indexed as

Peptide LibraryAmino Acid SequenceCollagenCombinatorial Chemistry TechniquesHumansHydrolysisMatrix MetalloproteinasesPeptide FragmentsProtein ConformationSequence HomologySubstrate SpecificityCollagenMatrix MetalloproteinasesPeptide FragmentsPeptide Libraryactivity-based fingerprintingcollagenconnective tissueextracellular matrixfluorescence resonance energy transfer (FRET)matrix metalloproteinase (MMP)peptide libraryproteolysistriple helix

Identifiers

PMID30185620
PMCPMC6204916
OpenAlexW2891256825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.