Evidence map›Paper›PMID 30185596›Full record

ArticleJournal of virology2018

Antibody-Mediated CD4 Depletion Induces Homeostatic CD4

Nitasha A Kumar, Julia B McBrien, Diane G Carnathan, Maud Mavigner, Cameron Mattingly, Erick R White, Federico Viviano, Steve E Bosinger, Ann Chahroudi, Guido Silvestri and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. The Hitchhiker Guide to CD4Frontiers in immunology · 2021
    Pooled it
  2. Article
  3. HIV reservoirs in lymphomagenesis: hidden driver in the era of viral suppression?Microbiology and molecular biology reviews : MMBR · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Prolonged experimental CD4Nature communications · 2023
    Article
  11. Substantial uneven proliferation of CD4Journal of virus eradication · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Nitasha A KumarYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Julia B McBrienYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Diane G CarnathanYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Maud MavignerDepartment of Pediatrics, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-9898-317X
Cameron MattinglyYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Erick R WhiteYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Federico VivianoYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Steve E BosingerYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Ann ChahroudiDepartment of Pediatrics, Emory University, Atlanta, Georgia, USA.
Guido SilvestriYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Mirko PaiardiniYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Thomas H VanderfordYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA thvande@emory.edu.
Emory University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Viral Testing Core-Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research CenterU42OD011023 · OD · EMORY UNIVERSITY · PI Matthew Ryan Gardner · 2018 to 2026
$17.5M
STUDIES OF NATURAL SIV INFECTION OF SOOTY MANGABEYSR37AI066998 · NIAID · EMORY UNIVERSITY · PI SILVESTRI, GUIDO · 2011 to 2020
$7.7M
Studies of Natural SIV Infection of Sooty MangabeysR01AI066998 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SILVESTRI, GUIDO · 2006 to 2010
$3.5M
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI066998NIAID NIH HHS R37 AI066998NIH HHS P51 OD011132NIH HHS U42 OD011023
6 · The paper itself

Abstract

A major barrier to human immunodeficiency virus (HIV) eradication is the long-term persistence of latently infected CD4

Indexed as

AnimalsAnti-Retroviral AgentsCD4-Positive T-LymphocytesCell ProliferationLymphocyte DepletionMacaca mulattaSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusViral LoadViremiaVirus ActivationVirus LatencyVirus ReplicationAnti-Retroviral Agentshomeostatic proliferationSIVSIV reservoir

Identifiers

PMID30185596
PMCPMC6206490
OpenAlexW2891616258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.