ArticleProceedings of the National Academy of Sciences of the United States of America2018
Elimination of the error signal in the superior colliculus impairs saccade motor learning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Head impulse compensatory saccades: Visual dependence is most evident in bilateral vestibular loss.PloS one · 2020Trial
- Impact of post stroke fatigue on saccadic eye movement control and learning through inflammatory mechanisms.Scientific reports · 2025Article
- In vivo parcellation of the human superior colliculus from brain-wide probabilistic connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcranial temporal interference stimulation precisely targets deep brain regions to regulate eye movements.Neuroscience bulletin · 2025Article
- Purkinje cells of the cerebellum control deceleration of tongue movements.PLoS biology · 2025Article
- Control of tongue movements by the Purkinje cells of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- The superior colliculus projection upon the macaque inferior olive.Brain structure & function · 2024Article
- Comparison of adaptation characteristics between visually and memory-guided saccades.Journal of neurophysiology · 2024Article
- The olivary input to the cerebellum dissociates sensory events from movement plans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Complex spikes perturb movements and reveal the sensorimotor map of Purkinje cells.Current biology : CB · 2023Article
- Neural mechanisms for the localization of unexpected external motion.Nature communications · 2023Article
- Article
- Rapid Input-Output Transformation between Local Field Potential and Spiking Activity during Sensation but not Action in the Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Interaction of dynamic error signals in saccade adaptation.Journal of neurophysiology · 2023Article
- Dual STDP processes at Purkinje cells contribute to distinct improvements in accuracy and speed of saccadic eye movements.PLoS computational biology · 2022Article
- Article
- Review
- The cost of correcting for error during sensorimotor adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cerebellar complex spikes multiplex complementary behavioral information.PLoS biology · 2021Article
- Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain.Journal of visualized experiments : JoVE · 2021Article
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2 authors.
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Abstract
When movements become dysmetric, the resultant motor error induces a plastic change in the cerebellum to correct the movement, i.e., motor adaptation. Current evidence suggests that the error signal to the cerebellum is delivered by complex spikes originating in the inferior olive (IO). To prove a causal link between the IO error signal and motor adaptation, several studies blocked the IO, which, unfortunately, affected not only the adaptation but also the movement itself. We avoided this confound by inactivating the source of an error signal to the IO. Several studies implicate the superior colliculus (SC) as the source of the error signal to the IO for saccade adaptation. When we inactivated the SC, the metrics of the saccade to be adapted were unchanged, but saccade adaptation was impaired. Thus, an intact rostral SC is necessary for saccade adaptation. Our data provide experimental evidence for the cerebellar learning theory that requires an error signal to drive motor adaptation.
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