Evidence map›Paper›PMID 30185559›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in

Govind Kunduri, Daniel Turner-Evans, Yutaka Konya, Yoshihiro Izumi, Kunio Nagashima, Stephen Lockett, Joost Holthuis, Takeshi Bamba, Usha Acharya, Jairaj K Acharya

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Regulating glial morphogenesis: insights fromFrontiers in cell and developmental biology · 2026
    Review
  5. Review
  6. The cyclic nucleotide binding sites of Swiss-Cheese, thebioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Glial Regulation of Circuit Wiring, Firing, and Expiring in theCold Spring Harbor perspectives in biology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Drosophila glia take shape to sculpt the nervous system.Current opinion in neurobiology · 2023
    Review
  18. Frontiers in molecular neuroscience · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Govind KunduriCancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD 21702.
Daniel Turner-EvansJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147.
Yutaka KonyaDepartment of Metabolomics, Kyushu University, Fukuoka 812-8582, Japan.
Yoshihiro IzumiDepartment of Metabolomics, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0003-4608-4652
Kunio NagashimaElectron Microscopy Laboratory, National Cancer Institute, Frederick, MD 21702.
Stephen LockettOptical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Joost HolthuisMolecular Cell Biology Division, University of Osnabrück, 49074 Osnabrück, Germany.
Takeshi BambaDepartment of Metabolomics, Kyushu University, Fukuoka 812-8582, Japan.
Usha AcharyaDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Jairaj K AcharyaCancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD 21702; acharyaj@mail.nih.gov.ORCID 0000-0001-7366-4228
Kyushu University · JPNational Cancer Institute · USFrederick National Laboratory for Cancer Research · USHoward Hughes Medical Institute · USOsnabrück University · DEUniversity of Massachusetts Chan Medical School · US

Funding

Phospholipid and Sphingolipid Signaling in DrosophilaZIABC010331 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ACHARYA, JAIRAJ · 2009 to 2025
$9.1M
Adaptation to ceramide involves AKT/FOXO regulated novel triglyceride lipasesR01GM110288 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ACHARYA, USHA R · 2015 to 2018
$1.4M
Howard Hughes Medical InstituteIntramural NIH HHS ZIA BC010331NIGMS NIH HHS R01 GM110288
6 · The paper itself

Abstract

Seizures induced by visual stimulation (photosensitive epilepsy; PSE) represent a common type of epilepsy in humans, but the molecular mechanisms and genetic drivers underlying PSE remain unknown, and no good genetic animal models have been identified as yet. Here, we show an animal model of PSE, in

Indexed as

AnimalsAnimals, Genetically ModifiedCell MembraneCerebral CortexDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsEpilepsy, ReflexHumansMaleMembrane ProteinsMutationNerve Tissue ProteinsNeurogliaNeuronsSphingomyelinsceramide phosphoethanolamineDrosophila ProteinsMembrane ProteinsNerve Tissue ProteinsSGMS1 protein, humanSphingomyelinsTransferases (Other Substituted Phosphate Groups)Drosophilaglianeuronphotosensitive epilepsysphingolipids

Identifiers

PMID30185559
PMCPMC6156639
OpenAlexW2890322608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.