Evidence map›Paper›PMID 30185553›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Altered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models.

Kyu-Sun Lee, Sungun Huh, Seongsoo Lee, Zhihao Wu, Ae-Kyeong Kim, Ha-Young Kang, Bingwei Lu

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 151 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 1 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 1 synthesis or guideline pooled it, 240 citations in OpenAlex.

  1. Pooled it
  2. Species-dependent activities of the PINK1-parkin axis.Translational neurodegeneration · 2026
    Review
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  4. Article
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  7. Article
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  9. Article
  10. ATM interaction with GRP94 modulates oncogenic receptor expression and signaling and microglial activation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Article
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  18. Gelated microvesicle-mediated delivery of mesenchymal stem cell mitochondria for the treatment of myocardial infarction.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Review
  20. Review

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kyu-Sun LeeDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Sungun HuhDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Seongsoo LeeDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Zhihao WuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Ae-Kyeong KimBioNanotechnology Research Center, Korea Research Institute of Biotechnology and Bioscience, 34141 Daejeon, Korea.
Ha-Young KangGwangju Center, Korea Basic Science Institute, 61186 Gwangju, Korea.
Bingwei LuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305; bingwei@stanford.edu.
Korea Research Institute of Bioscience and Biotechnology · KRStanford University · USKorea Basic Science Institute · KR

Funding

Molecular Genetic Analysis of TORC1 and TORC2 Signaling in Neuronal MaintenanceR01NS084412 · NINDS · STANFORD UNIVERSITY · PI Bingwei Lu · 2014 to 2026
$4.9M
Role of PAR-1 Kinase in SynaptogenesisR01MH080378 · NIMH · STANFORD UNIVERSITY · PI LU, BINGWEI · 2009 to 2018
$4.0M
Genetic Control of Neural Stem Cell HomeostasisR01NS083417 · NINDS · STANFORD UNIVERSITY · PI LU, BINGWEI · 2013 to 2022
$3.5M
NIMH NIH HHS R01 MH080378NINDS NIH HHS R01 NS083417NINDS NIH HHS R01 NS084412
6 · The paper itself

Abstract

Calcium (Ca

Indexed as

AnimalsAnimals, Genetically ModifiedCalciumChelating AgentsDisease Models, AnimalDopaminergic NeuronsDrosophila melanogasterDrosophila ProteinsEndoplasmic ReticulumGlycogen Synthase Kinase 3HumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Loss of Function MutationMitochondriaParkinson DiseaseProtein Serine-Threonine KinasesCalciumChelating AgentsDrosophila ProteinsGlycogen Synthase Kinase 3Leucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanMiro protein, DrosophilaPar-1 protein, DrosophilaPINK1 protein, DrosophilaProtein Serine-Threonine KinasesPTEN-Induced Putative Kinaserho GTP-Binding Proteinscalcium homeostasisER–mitochondria contact siteMiroParkinson’s diseasePINK1

Identifiers

PMID30185553
PMCPMC6156612
OpenAlexW2889803986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.