Evidence map›Paper›PMID 30185547›Full record

ArticleCancer research2018

Pooled Analysis of Nine Cohorts Reveals Breast Cancer Risk Factors by Tumor Molecular Subtype.

Mia M Gaudet, Gretchen L Gierach, Brian D Carter, Juhua Luo, Roger L Milne, Elisabete Weiderpass, Graham G Giles, Rulla M Tamimi, A Heather Eliassen, Bernard Rosner and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in Cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05030519 (A Study of Diarrhea and Intestinal Flora Changes Caused by Pyrotinib in Breast Cancer), which is not on this map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05030519 unknown statusnot on this mapstarted 2021, after this paper: background citation

A Study of Diarrhea and Intestinal Flora Changes Caused by Pyrotinib in Breast Cancer

TypeobservationalSponsorZhejiang Cancer HospitalRan2021 to 2022Enrolled50ConditionsBreast CancerArmsPyrotinib
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Epidemiology, early detection, and management of breast cancer in China: A comprehensive review.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Causal Effects of Breast Cancer Risk Factors across Hormone Receptor Breast Cancer Subtypes: A Two-Sample Mendelian Randomization Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Functions and mechanisms of RNA mInternational journal of oncology · 2024
    Review
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mia M GaudetEpidemiology Research Program, American Cancer Society, Atlanta, Georgia. mia.gaudet@cancer.org.
Gretchen L GierachDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Brian D CarterEpidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Juhua LuoDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, Indiana.
Roger L MilneCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia; and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.ORCID 0001-5764-7268
Elisabete WeiderpassDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID 0003-2237-0128
Graham G GilesCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia; and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.ORCID 0003-4946-9099
Rulla M TamimiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
A Heather EliassenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Bernard RosnerChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Alicja WolkDepartment of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.ORCID 0001-7387-6845
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Karen L MargolisHealthPartners Institute for Education and Research, Minneapolis, Minnesota.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Montserrat Garcia-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Louise A BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0003-3853-8562

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA050385NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201100046CWHI NIH HHS HHSN268201100001C
6 · The paper itself

Abstract

Various subtypes of breast cancer defined by estrogen receptor (ER), progesterone receptor (PR), and HER2 exhibit etiologic differences in reproductive factors, but associations with other risk factors are inconsistent. To clarify etiologic heterogeneity, we pooled data from nine cohort studies. Multivariable, joint Cox proportional hazards regression models were used to estimate HRs and 95% confidence intervals (CI) for molecular subtypes. Of 606,025 women, 11,741 invasive breast cancers with complete tissue markers developed during follow-up: 8,700 luminal A-like (ER

Indexed as

AdultAgedBiomarkers, TumorBreast NeoplasmsEstrogen Receptor alphaFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedMultivariate AnalysisProportional Hazards ModelsProspective StudiesReceptors, ProgesteroneRisk FactorsTriple Negative Breast NeoplasmsBiomarkers, TumorESR1 protein, humanEstrogen Receptor alphaReceptors, Progesterone

Identifiers

PMID30185547
PMCPMC6223627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.