Evidence map›Paper›PMID 30185516›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization.

Morgan F Wade, Morgan K Collins, Denay Richards, Douglas G Mack, Allison K Martin, Charles A Dinarello, Andrew P Fontenot, Amy S McKee

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. NADAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Interleukin-1 signaling and CD4Frontiers in immunology · 2025
    Article
  3. Article
  4. A comprehensive summary of disease variants implicated in metal allergy.Journal of toxicology and environmental health. Part B, Critical reviews · 2022
    Review
  5. Innate and Adaptive Immunity in Noninfectious Granulomatous Lung Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Review
  6. Article
  7. Pulmonary Macrophage Cell Death in Lung Health and Disease.American journal of respiratory cell and molecular biology · 2021
    Review
  8. Age-associated B Cells Appear in Patients with Granulomatous Lung Diseases.American journal of respiratory and critical care medicine · 2020
    Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Morgan F WadeDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Morgan K CollinsDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Denay RichardsDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Douglas G MackDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Allison K MartinDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Charles A DinarelloDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0002-5073-8316
Andrew P FontenotDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0003-4095-512X
Amy S McKeeDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045; amy.mckee@ucdenver.edu.ORCID 0000-0002-9268-5574
University of Colorado Anschutz Medical Campus · US

Funding

Yeast-based HTS Assay Technologies for ProteasesR01AI015614 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DINARELLO, CHARLES ANTHONY · 1985 to 2025
$8.5M
Investigating paclitaxel treatment in a pre-clinical model of Schistosoma-pulmonary hypertensionR01HL135872 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Brian Barkley Graham · 2017 to 2026
$5.1M
Interactions between antigen-specific effector and regulatory T cells in beryllium-induced diseaseR01ES025534 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI FONTENOT, ANDREW P. · 2016 to 2020
$2.1M
Innate effects of beryllium on pulmonarydendritic cell function in chronic beryllium diseaseR01HL126736 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKEE, AMY STRAW · 2016 to 2020
$1.9M
NHLBI NIH HHS R01 HL126736NHLBI NIH HHS R01 HL135872NIAID NIH HHS R01 AI015614NIEHS NIH HHS R01 ES025534
6 · The paper itself

Abstract

Metal-induced hypersensitivity is driven by dendritic cells (DCs) that migrate from the site of exposure to the lymph nodes, upregulate costimulatory molecules, and initiate metal-specific CD4

Indexed as

AllergensAnimalsBerylliosisBerylliumCD4-Positive T-LymphocytesCell DifferentiationCell MovementCells, CulturedChronic DiseaseDendritic CellsEnzyme-Linked Immunospot AssayHumansHypersensitivityImmunizationLungLymphocyte ActivationAllergensBerylliumIL1R1 protein, mouseMyeloid Differentiation Factor 88Receptors, Interleukin-1 Type IToll-Like Receptor 9

Identifiers

PMID30185516
PMCPMC6191034
OpenAlexW2890129820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.