Evidence map›Paper›PMID 30185513›Full record

ArticlemSphere2018

Germinant Synergy Facilitates Clostridium difficile Spore Germination under Physiological Conditions.

Travis J Kochan, Michelle S Shoshiev, Jessica L Hastie, Madeline J Somers, Yael M Plotnick, Daniela F Gutierrez-Munoz, Elissa D Foss, Alyxandria M Schubert, Ashley D Smith, Sally K Zimmerman and 2 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Acidification-dependent suppression ofInfection and immunity · 2026
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  6. Phenotypic analysis of variousApplied and environmental microbiology · 2025
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  8. Phenotypic analysis of variousbioRxiv : the preprint server for biology · 2025
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  9. Article
  10. Correlating Antibiotic-Induced Dysbiosis toACS infectious diseases · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Intestinal and fecal pH in human health.Frontiers in microbiomes · 2023
    Review
  15. Article
  16. Capturing the environment of the Clostridioides difficile infection cycle.Nature reviews. Gastroenterology & hepatology · 2022
    Review
  17. Article
  18. Review
  19. Opportunities for Nanomedicine inAntibiotics (Basel, Switzerland) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Travis J KochanDepartment of Microbiology and Immunology. University of Michigan Medical School, Ann Arbor, Michigan, USA.
Michelle S ShoshievDepartment of Microbiology and Immunology. University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jessica L HastieCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Madeline J SomersDepartment of Microbiology and Immunology. University of Michigan Medical School, Ann Arbor, Michigan, USA.
Yael M PlotnickDepartment of Microbiology and Immunology. University of Michigan Medical School, Ann Arbor, Michigan, USA.
Daniela F Gutierrez-MunozCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Elissa D FossCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Alyxandria M SchubertCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Ashley D SmithCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Sally K ZimmermanCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Paul E CarlsonCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA paul.carlson@fda.hhs.gov pchanna@umich.edu.
Philip C HannaDepartment of Microbiology and Immunology. University of Michigan Medical School, Ann Arbor, Michigan, USA paul.carlson@fda.hhs.gov pchanna@umich.edu.
University of Michigan–Ann Arbor · USUnited States Food and Drug Administration · USCenter for Biologics Evaluation and Research · US

Funding

Characterization of the Mechanism of Glycine induced Germination of Clostridium difficile SporesF31AI126651 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOCHAN, TRAVIS JOSEPH · 2016 to 2018
$81k
NIAID NIH HHS F31 AI126651
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amino AcidsAnimalsBacterial ProteinsBile Acids and SaltsCalciumCalcium SignalingClostridioides difficileHydrogen-Ion ConcentrationIntestine, SmallMiceMice, Inbred C57BLSpores, BacterialAmino AcidsBacterial ProteinsBile Acids and SaltsCalciumClostridium difficilegerminationspore

Identifiers

PMID30185513
PMCPMC6126144
OpenAlexW2891442164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.