Evidence map›Paper›PMID 30185429›Full record

ArticleGenetics2018

Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in

Arneet L Saltzman, Mark W Soo, Reta Aram, Jeannie T Lee

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. ThemicroPublication biology · 2024
    Article
  5. Article
  6. Article
  7. Assessing theBio-protocol · 2021
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Arneet L SaltzmanDepartment of Molecular Biology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts 02114 arneet.saltzman@utoronto.ca lee@molbio.mgh.harvard.edu.ORCID 0000-0002-5827-3322
Mark W SooDepartment of Molecular Biology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts 02114.
Reta AramDepartment of Cell and Systems Biology, University of Toronto, Ontario M5S 3G5, Canada.
Jeannie T LeeDepartment of Molecular Biology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts 02114 arneet.saltzman@utoronto.ca lee@molbio.mgh.harvard.edu.ORCID 0000-0001-7786-8850
Howard Hughes Medical Institute · USUniversity of Toronto · CA

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Polycomb complexes targeted to specific loci by non-coding RNA co-factorsR01GM090278 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, JEANNIE T · 2010 to 2017
$3.7M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM090278NIH HHS P40 OD010440
6 · The paper itself

Abstract

Chromatin modifications, including methylation of histone H3 at lysine 27 (H3K27me) by the Polycomb group proteins, play a broadly conserved role in the maintenance of cell fate. Diverse chromatin organization modifier (chromo) domain proteins act as "readers" of histone methylation states. However, understanding the functional relationships among chromo domains and their roles in the inheritance of gene expression patterns remains challenging. Here, we identify two chromo-domain proteins, CEC-1 and CEC-6, as potential readers of H3K27me in

Indexed as

Amino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsFertilityHeterochromatinHistonesLongevityLysineMaleMethylationProtein DomainsSpermatozoaTemperatureCaenorhabditis elegans ProteinsHeterochromatinHistonesLysineCECC. eleganschromodomain proteinsgene silencingH3K27me3histone methyl-lysine readersmortal germlinePolycomb proteinsPRC2worm

Identifiers

PMID30185429
PMCPMC6218232
OpenAlexW2891444489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.