ArticleG3 (Bethesda, Md.)2018
Estimating Asian Contribution to the Brazilian Population: A New Application of a Validated Set of 61 Ancestry Informative Markers.
Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
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- Investigation of Genetic Factors and Clinical Data in Breast Cancer Highlights the Importance of Breastfeeding and Cancer History.Current issues in molecular biology · 2023Article
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- The Search for Cancer Biomarkers: Assessing the Distribution of INDEL Markers in Different Genetic Ancestries.Current issues in molecular biology · 2022Article
- Variants in theNutrients · 2022Article
- Ancestral genetic legacy of the extant population of Argentina as predicted by autosomal and X-chromosomal DIPs.Molecular genetics and genomics : MGG · 2021Article
- Genetic ancestry plays a central role in population pharmacogenomics.Communications biology · 2021Article
- Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.BMC cancer · 2020Article
- Investigation of INDEL variants in apoptosis: the relevance to gastric cancer.BMC medical genetics · 2020Article
- The Biological Role of Sponge Circular RNAs in Gastric Cancer: Main Players or Coadjuvants?Cancers · 2020Article
- Copy number variation (CNV) identification, interpretation, and database from Brazilian patients.Genetics and molecular biology · 2020Article
- Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population.PloS one · 2020Article
- Role of Genetic Ancestry in 1,002 Brazilian Colorectal Cancer Patients From Barretos Cancer Hospital.Frontiers in oncology · 2020Article
- miRNome Reveals New Insights Into the Molecular Biology of Field Cancerization in Gastric Cancer.Frontiers in genetics · 2019Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estimates of different ancestral proportions in admixed populations are very important in population genetics studies, especially for the detection of population substructure effects in studies of case-control associations. Brazil is one of the most heterogeneous countries in the world, both from a socio-cultural and a genetic point of view. In this work, we investigated a previously developed set of 61 ancestry informative markers (AIM), aiming to estimate the proportions of four different ancestral groups (African, European, Native American and Asian) in Brazilian populations. To the best of our knowledge, this is the first study to use a set of AIM to investigate the genetic contribution of all four main parental populations to the Brazilian population, including Asian contribution. All selected markers were genotyped through multiplex PCR and capillary electrophoresis. The set was able to successfully differentiate the four ancestral populations (represented by 939 individuals) and identify their genetic contributions to the Brazilian population. In addition, it was used to estimate individual interethnic admixture of 1050 individuals from the Southeast region of Brazil and it showed that these individuals present a higher European ancestry contribution, followed by African, Asian and Native American ancestry contributions. Therefore, the 61 AIM set has proved to be a valuable tool to estimate individual and global ancestry proportions in populations mainly formed by these four groups. Our findings highlight the importance of using sets of AIM to evaluate population substructure in studies carried in admixed populations, in order to avoid misinterpretation of results.
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