Evidence map›Paper›PMID 30185420›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2019

Lobular Carcinomas

Ju Youn Lee, Michail Schizas, Felipe C Geyer, Pier Selenica, Salvatore Piscuoglio, Rita A Sakr, Charlotte K Y Ng, Jose V Scarpa Carniello, Russell Towers, Dilip D Giri and 8 more

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Breast Cancer Polygenic Risk Score Associated with Outcomes after In Situ Breast Disease.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  4. Article
  5. Article
  6. Molecular Basis of Breast Tumor Heterogeneity.Advances in experimental medicine and biology · 2025
    Review
  7. Article
  8. Nonlobular Invasive Breast Carcinomas with Biallelic Pathogenic CDH1 Somatic Alterations: A Histologic, Immunophenotypic, and Genomic Characterization.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024
    Article
  9. Article
  10. Article
  11. Clinical Implications of APOBEC3-Mediated Mutagenesis in Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Review
  12. Article
  13. Article
  14. Mechanisms of breast cancer metastasis.Clinical & experimental metastasis · 2022
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Ju Youn Lee *Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Michail Schizas *Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Felipe C Geyer *Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Pier Selenica *Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Salvatore PiscuoglioDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-2686-2939
Rita A SakrDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Charlotte K Y NgDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-6100-0026
Jose V Scarpa CarnielloDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Russell TowersDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Dilip D GiriDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Victor P de AndradeDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-2243-8834
Anastasios D PapanastasiouDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Agnes VialeCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Reuben S HarrisHoward Hughes Medical Institute, Masonic Cancer Center, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota.
David B SolitCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Britta WeigeltDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jorge S Reis-FilhoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. reisfilj@mskcc.org tking7@bwh.harvard.edu.
Tari A KingDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York. reisfilj@mskcc.org tking7@bwh.harvard.edu.
Memorial Sloan Kettering Cancer Center · USHoward Hughes Medical Institute · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeLobular carcinoma

resultsWES of 43 LCIS lesions revealed a genomic profile similar to that previously reported for ILCs, with

conclusionsOur findings support the contention that LCIS has a repertoire of somatic genetic alterations similar to that of ILCs, and likely constitutes a nonobligate precursor of breast cancer. Intralesion genetic heterogeneity is observed in LCIS and should be considered in studies aiming to develop biomarkers of progression from LCIS to more advanced lesions.

Indexed as

Genetic HeterogeneityGenetic VariationBreast Carcinoma In SituCarcinoma, LobularClonal EvolutionDisease ProgressionExome SequencingHigh-Throughput Nucleotide SequencingHumansMutationNeoplasm MetastasisNeoplasm StagingTumor Burden

Identifiers

PMID30185420
PMCPMC6726436
OpenAlexW2889853534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.