Evidence map›Paper›PMID 30185206›Full record

ArticleRadiation oncology (London, England)2018

Imaging dose and secondary cancer risk in image-guided radiotherapy of pediatric patients.

Yvonne Dzierma, Katharina Mikulla, Patrick Richter, Katharina Bell, Patrick Melchior, Frank Nuesken, Christian Rübe

Open access · goldAbstract read
In one paragraph

Article in Radiation oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

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  7. Investigation of the beam width and profile of kilovoltage CBCT using different measurement techniques and analysis of the dosimetric effects of beam parameters.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
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  17. Out-of-field dose in stereotactic radiotherapy for paediatric patients.Physics and imaging in radiation oncology · 2021
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  18. Article
  19. How low can you go? A CBCT dose reduction study.Journal of applied clinical medical physics · 2021
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  20. Evaluation of patient organ doses from kilovoltage cone-beam CT imaging in radiation therapy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yvonne DziermaDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical Centre, Kirrberger Str. Geb. 6.5, 66421, Homburg, Saar, Germany. Yvonne.dzierma@uks.eu.
Katharina MikullaDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical Centre, Kirrberger Str. Geb. 6.5, 66421, Homburg, Saar, Germany.
Patrick RichterDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical Centre, Kirrberger Str. Geb. 6.5, 66421, Homburg, Saar, Germany.
Katharina BellDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical Centre, Kirrberger Str. Geb. 6.5, 66421, Homburg, Saar, Germany.
Patrick MelchiorDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical Centre, Kirrberger Str. Geb. 6.5, 66421, Homburg, Saar, Germany.
Frank NueskenDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical Centre, Kirrberger Str. Geb. 6.5, 66421, Homburg, Saar, Germany.
Christian RübeDepartment of Radiotherapy and Radiation Oncology, Saarland University Medical Centre, Kirrberger Str. Geb. 6.5, 66421, Homburg, Saar, Germany.
Saarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDaily image-guided radiotherapy (IGRT) can contribute to cover extended body volumes with low radiation dose. The effect of additional imaging dose on secondary cancer development is modelled for a collective of children with Morbus Hodgkin.

methodsEleven radiotherapy treatment plans from pediatric patients with Hodgkin's lymphoma were retrospectively analyzed, including imaging dose from scenarios using different energies (kV/MV) and planar/cone-beam computed tomography (CBCT) techniques. In addition to assessing the effect of imaging dose on organs at risk, the excess average risk (EAR) for developing a secondary carcinoma of the lung or breast was modelled.

resultsAlthough the variability between the patients is relatively large due to the different target volumes, the additional EAR due to imaging can be consistently determined. For daily 6MV CBCT, the EAR for developing a secondary cancer at age 50 is over 3 cases per 10

conclusionsDaily imaging can be performed with an additional secondary cancer risk of less than 1 per 10

Indexed as

AdolescentChildChild, PreschoolCone-Beam Computed TomographyFemaleGermanyHodgkin DiseaseHumansMaleNeoplasms, Radiation-InducedNeoplasms, Second PrimaryPhantoms, ImagingRadiation DosageRadiation ExposureRadiotherapy DosageRadiotherapy, Image-GuidedImage-guided radiotherapyImaging dose in pediatric patientsRadiotherapy for Hodgkin lymphomaSecondary cancer risk

Identifiers

PMID30185206
PMCPMC6125956
OpenAlexW2889856977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.