Evidence map›Paper›PMID 30185189›Full record

ArticleJournal of neuroinflammation2018

A comparison of brain magnetic resonance imaging lesions in multiple sclerosis by race with reference to disability progression.

Yuri Nakamura, Laura Gaetano, Takuya Matsushita, Altermatt Anna, Till Sprenger, Ernst-Wilhelm Radue, Jens Wuerfel, Lorena Bauer, Michael Amann, Koji Shinoda and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Brain volume is related to neurological impairment and to copper overload in Wilson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuri NakamuraDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Laura GaetanoMedical Image Analysis Center (MIAC AG), Marktgasse 8, 4051, Basel, Switzerland.
Takuya MatsushitaDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Altermatt AnnaMedical Image Analysis Center (MIAC AG), Marktgasse 8, 4051, Basel, Switzerland.
Till SprengerDKD Helios Klinik Wiesbaden, Aukammallee 33, 65191, Wiesbaden, Germany.
Ernst-Wilhelm RadueBiomedical Research and Education GmbH, Mittlere Strasse 91, 4031, Basel, Switzerland.
Jens WuerfelMedical Image Analysis Center (MIAC AG), Marktgasse 8, 4051, Basel, Switzerland.
Lorena BauerMedical Image Analysis Center (MIAC AG), Marktgasse 8, 4051, Basel, Switzerland.
Michael AmannMedical Image Analysis Center (MIAC AG), Marktgasse 8, 4051, Basel, Switzerland.
Koji ShinodaDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Noriko IsobeDepartment of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Ryo YamasakiDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Takahiko SaidaInstitute of Neurotherapeutics, 16-1 Nishinokyoukasugachou, Nakagyo-ku, Kyoto, 604-8453, Japan.
Ludwig KapposNeurology and Department of Biomedicine, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
Jun-Ichi KiraDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. kira@neuro.med.kyushu-u.ac.jp.

Funding

Japan Agency for Medical Research and Development Practical Research Project for Rare/Intractable DiseasesJapanese Multiple Sclerosis Society noneJapan Society for the Promotion of Science JSPS KAKENHI Grant Number 15K09341Japan Society for the Promotion of Science JSPS KAKENHI Grant Number 17K16125Japan Society for the Promotion of Science JSPS KAKENHI Grant Numbers 16K09694Japan Society for the Promotion of Science (JP) JSPS KAKENHI Grant Number 16H02657Ministry of Education, Culture, Sports, Science and Technology MEXT KAKENHI Grant Number 25117012Ministry of Health, Labour and Welfare (JP) H29-Nanchitou (Nan)-Ippan-043
6 · The paper itself

Abstract

backgroundWe compared the magnetic resonance imaging (MRI) features between Japanese and Caucasian patients with multiple sclerosis (MS), and identified the relationships between MRI features and disability.

methodsFrom the baseline data of phase II fingolimod trials, 95 Japanese and 246 Caucasian relapsing-remitting MS patients were enrolled. The number, volume, and distribution of brain MRI lesions were evaluated using T2-weighted (T2W) images. Cross-sectional total normalized brain volume (NBV), normalized cortical gray matter volume, normalized deep gray matter volume (NDGMV), normalized white matter volume (NWMV), and normalized thalamic volume were measured.

resultsJapanese patients had significantly lower Expanded Disability Status Scale (EDSS) scores than Caucasian patients (mean 2.0 vs. 2.3, p = 0.008), despite a similar disease duration. Japanese patients showed a trend towards fewer T2W-lesions (median 50 vs. 65, p = 0.08) and significantly lower frequencies of cerebellar and parietal lobe lesions (p = 0.02 for both) than Caucasian patients. There were no differences in T2W-lesion volume between races, whereas Japanese patients had a significantly larger T2W-lesion volume per lesion compared with Caucasian patients (median 140 mm

conclusionsGray matter atrophy is a common denominator for disability in Japanese and Caucasian patients. Additional contributory factors for disability include T2W-lesion volume in Japanese patients and white matter atrophy in Caucasian patients. Less frequent parietal and cerebellar involvement with fewer T2W-lesions may underlie milder disability in Japanese patients.

Indexed as

Disease ProgressionMultiple SclerosisPersons with DisabilitiesAdultBrainCross-Sectional StudiesDisability EvaluationFemaleHumansImage Processing, Computer-AssistedJapanMagnetic Resonance ImagingMaleMiddle AgedReference ValuesSeverity of Illness IndexBrain lesionsBrain volumeDisabilityMagnetic resonance imagingMultiple sclerosisProgressionRace

Identifiers

PMID30185189
PMCPMC6125988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.