ArticleSchizophrenia bulletin2019
Burden for Parents of Patients With Schizophrenia-A Nationwide Comparative Study of Parents of Offspring With Rheumatoid Arthritis, Multiple Sclerosis, Epilepsy, and Healthy Controls.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Prevalence of violence by people living with severe mental illness against their relatives and its associated impacts: A systematic review.Acta psychiatrica Scandinavica · 2023Pooled it
- Pooled it
- The genetic basis for the inverse relationship between rheumatoid arthritis and schizophrenia.Molecular genetics & genomic medicine · 2020Pooled it
- Associations of mental disorders in children with parents' subsequent mental disorders: nationwide cohort study from Finland and Denmark.The British journal of psychiatry : the journal of mental science · 2026Article
- Stigma and quality of life in hospitalized schizophrenia patient-family caregiver dyads in Northern China: an actor-partner interdependence model analysis.Frontiers in psychiatry · 2026Article
- Mental health-related sickness absences in parents of children with mental disorders or neurodevelopmental conditions.Epidemiology and psychiatric sciences · 2025Article
- Article
- Association of a child's mental disorder with parental income and employment: analysis of nationwide register-based cohorts in Finland and Denmark.BMJ mental health · 2025Article
- Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic.Physiological research · 2024Review
- Article
- Schizophrenia and Rheumatoid Arthritis Genetic Scenery: Potential Non-HLA Genes Involved in Both Diseases Relationship.The Yale journal of biology and medicine · 2024Article
- Leo program, a short multi-family skill-based psychoeducational program for caregivers of relatives living with a severe mental disorder: a retrospective pilot study.Frontiers in psychiatry · 2024Article
- A 1-Day Training Course to Disseminate the BREF Psychoeducational Program to Caregivers and Promote Network Establishment between Psychiatry Departments and Family Associations.Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry · 2023Article
- Caregiving-related experiences associated with depression severity and its symptomatology among caregivers of individuals with a severe mental disorder: an online cross-sectional study.European archives of psychiatry and clinical neuroscience · 2023Article
- Understanding the support needs of parents of children with obsessive-compulsive disorder: a qualitative descriptive study in the UK.BMC psychiatry · 2023Article
- Family psychoeducation to improve outcome in caregivers and patients with schizophrenia: a randomized clinical trial.Frontiers in psychiatry · 2023Article
- COVID-19 lockdown - who cares? The first lockdown from the perspective of relatives of people with severe mental illness.BMC public health · 2022Article
- Family caregiving and chronic illness management in schizophrenia: positive and negative aspects of caregiving.BMC psychology · 2022Article
- Understanding the Economic Value and Impacts on Informal Carers of People Living with Mental Health Conditions.International journal of environmental research and public health · 2022Article
- Societal Costs of Schizophrenia in Denmark: A Nationwide Matched Controlled Study of Patients and Spouses Before and After Initial Diagnosis.Schizophrenia bulletin · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe study aimed to (1) compare the risk of health care use, adverse health status, and work productivity loss of parents of patients with schizophrenia to parents of patients with multiple sclerosis (MS), rheumatoid arthritis (RA), epilepsy, and healthy controls; and (2) evaluate such outcome measures while considering disease severity of schizophrenia.
methodsBased on linkage of Swedish registers, at least one parent was included (n = 18215) of patients with schizophrenia (information 2006-2013, n = 10883). Similarly, parental information was linked to patients with MS, RA, epilepsy, and matched healthy controls, comprising 11292, 15516, 34715, and 18408 parents, respectively. Disease severity of schizophrenia was analyzed. Different regression models yielding odds ratios (OR), hazard ratios (HR), or relative risks (RR) with 95% confidence intervals (CI) were run.
resultsPsychiatric health care use, mainly due to anxiety and affective disorders, showed a strongly increasing trend for parents of patients with schizophrenia throughout the observation period. During the follow-up, these parents had an up to 2.7 times higher risk of specialized psychiatric health care and receipt of social welfare benefits than other parents. Parents of the moderately severely ill patients with schizophrenia had higher risk estimates for psychiatric health care (RR: 1.12; 95% CI: 1.07-1.17) compared with parents of least severely ill patients.
conclusionsParents of patients with schizophrenia have a considerably higher risk of psychiatric health care and social welfare benefit receipt than other parents. Psychiatric health care use worsens over time and with increasing disease severity of the offspring.
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Registered trials
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