ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019
Antiretroviral Concentrations in Hair Strongly Predict Virologic Response in a Large Human Immunodeficiency Virus Treatment-naive Clinical Trial.
Registry-linked trialAbstract read
In one paragraph
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05333679 (Urine Tenofovir Point-of-care Test to Identify Patients in Need of ART Adherence Support), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urine Tenofovir Point-of-care Test to Identify Patients in Need of ART Adherence Support (UTRA Study)
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antiretroviral Concentration in Hair as a Measure for Antiretroviral Medication Adherence: A Systematic Review of Global Literature.AIDS and behavior · 2020Pooled it
- The multifaceted role of hair as a biospecimen: recent advances in precision medicine and forensic science.Experimental & molecular medicine · 2025Review
- Point-of-care urine tenofovir monitoring of adherence to drive interventions for HIV treatment and prevention.Expert review of molecular diagnostics · 2024Review
- Perspectives of people living with HIV and health workers about a point-of-care adherence assay: a qualitative study on acceptability.AIDS care · 2023Article
- Feasibility of remote self-collection of dried blood spots, hair, and nails among people with HIV with hazardous alcohol use.Alcohol, clinical & experimental research · 2023Article
- Agreement Between Measures of Adherence to Isoniazid Preventive Therapy Among People With HIV in Uganda.Open forum infectious diseases · 2022Article
- Sample preparation techniques for extraction of vitamin D metabolites from non-conventional biological sample matrices prior to LC-MS/MS analysis.Analytical and bioanalytical chemistry · 2022Review
- Hair Zidovudine Concentrations Predict Virologic Outcomes Among People Living with HIV/AIDS in China.Patient preference and adherence · 2022Article
- Effect of Text Messaging Plus Peer Navigation on Viral Suppression Among Youth With HIV in the iCARE Nigeria Pilot Study.Journal of acquired immune deficiency syndromes (1999) · 2021Article
- Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide-based ART.Drug testing and analysis · 2021Article
- Development and validation of a liquid chromatography-tandem mass spectrometry method for quantifying delamanid and its metabolite in small hair samples.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2021Article
- LC-MS/MS Quantification of Nevirapine and Its Metabolites in Hair for Assessing Long-Term Adherence.Molecules (Basel, Switzerland) · 2020Article
- Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions.Current HIV/AIDS reports · 2020Review
- Influence of hair treatments on detection of antiretrovirals by mass spectrometry imaging.The Analyst · 2020Article
- Randomized controlled trial of a positive affect intervention to reduce HIV viral load among sexual minority men who use methamphetamine.Journal of the International AIDS Society · 2019Article
- Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging of Human Hair to Characterize Longitudinal Profiles of the Antiretroviral Maraviroc for Adherence Monitoring.Analytical chemistry · 2019Article
- Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women.AIDS (London, England) · 2019Article
- Measuring Adherence to Antiretroviral Therapy via Hair Concentrations in India.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Association of anti-tuberculosis drug concentrations in hair and treatment outcomes in MDR- and XDR-TB.ERJ open research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Monica GandhiDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco.
Peter BacchettiDepartment of Epidemiology and Biostatistics, University of California, San Francisco.
Igho OfokotunDivision of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia.
Chengshi JinDepartment of Epidemiology and Biostatistics, University of California, San Francisco.
Heather J RibaudoDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
David W HaasDivision of Infectious Diseases, Department of Medicine, Vanderbilt University.
Anandi N ShethDivision of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia.
Howard HorngDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco.
Nhi PhungDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco.
Karen KunczeDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco.
Hideaki OkochiDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco.
Raphael J LandovitzDivision of Infectious Diseases, Department of Medicine, University of California, Los Angeles.
Jeffrey LennoxDivision of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia.
Judith S CurrierDivision of Infectious Diseases, Department of Medicine, University of California, Los Angeles.
AIDS Clinical Trials Group (ACTG) 5257 Study Team
Funding
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1MStatistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6MVanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MValidation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8MVirology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6MVirology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9MStatistical and Data Management Center for the AIDS Clinical Trials GroupU01AI068634 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI HUGHES, MICHAEL DAVID · 2006 to 2010
$71.9MUCLA AIDS Prevention and Treatment Clinical Trials UnitUM1AI069424 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Judith S. Currier, RAPHAEL J LANDOVITZ · 2012 to 2026
$51.8MClinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MVanderbilt HIV Clinical Trials Unit (CTU)UM1AI069439 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David W Haas, Spyros A Kalams · 2012 to 2026
$33.1MSan Francisco Vaccine and Prevention UnitUM1AI069496 · NIAID · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI Susan Buchbinder, Diane V Havlir · 2012 to 2026
$30.5MTennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5MNCATS NIH HHS TL1 TR000144NCATS NIH HHS TL1 TR001871NCATS NIH HHS UL1 TR002243NCATS NIH HHS UL1 TR002548NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI110527NIAID NIH HHS R01 AI077505NIAID NIH HHS R01 AI098472NIAID NIH HHS R37 AI098472NIAID NIH HHS U01 AI068634NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069424NIAID NIH HHS UM1 AI069439NIAID NIH HHS UM1 AI069496NIAID NIH HHS UM1 AI106701
Abstract
Concentrations of antiretrovirals in hair are associated with virologic outcomes in cohorts of human immunodeficiency virus (HIV)-positive individuals but have never been examined in a clinical trial. We show for the first time the predictive utility of hair antiretroviral concentrations in a large HIV treatment-naive trial (AIDS Clinical Trials Group protocol A5257).
Indexed as
HIV-1AdolescentAdultAgedAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveFemaleHairHIV InfectionsHumansMaleMiddle AgedRandomized Controlled Trials as TopicTissue DistributionTreatment FailureTreatment OutcomeAnti-HIV AgentsA5257 studyAIDS Clinical Trials Group (ACTG)hair concentrationsHIVnon-NNRTI regimens
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Registered trials
NCT05333679ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.