Trial reportPloS one2018
Prolonged fasting-induced metabolic signatures in human skeletal muscle of lean and obese men.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review.Frontiers in nutrition · 2021Pooled it
- Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies.Metabolomics : Official journal of the Metabolomic Society · 2019Pooled it
- Fasting-induced glucose intolerance is not impacted by the addition of daily exercise: A randomized crossover study.The Journal of physiology · 2026Trial
- Associations of Circulating Osteoglycin With Bone Parameters and Metabolic Markers in Patients With Diabetes.Frontiers in endocrinology · 2021Trial
- Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults.GeroScience · 2020Trial
- A model mimicking catabolic inflammatory disease; a controlled randomized study in humans.PloS one · 2020Trial
- Redundancy in regulation of lipid accumulation in skeletal muscle during prolonged fasting in obese men.Physiological reports · 2019Trial
- Exercise Training in the Fasted State During the Month of Ramadan: Acutely Ergolytic but Possibly Chronically Ergogenic? A Narrative Review with Systematic Search and Methodological Quality Assessment.Sports medicine - open · 2026Review
- Marked Increases in Continuous Glucose Monitor-Detected Hypoglycemia During a Seven-Day Water-Only Fast in Healthy Men and Women.Journal of diabetes science and technology · 2026Article
- Global loss of metabolic responsiveness and elevated enzyme in leptin deficient obese mice during starvation.NPJ systems biology and applications · 2026Article
- Insulin Resistance at the Crossroads of Metabolic Inflammation, Cardiovascular Disease, Organ Failure and Cancer.Biomolecules · 2025Review
- Body weight regulation models in humans: insights for testing their validity.Nature reviews. Endocrinology · 2025Review
- Metabolic stress and muscle mechanics: Acute response of isolated soleus and EDL muscles to prolonged fasting in mice with distinct muscle phenotypes.Biology open · 2025Article
- Article
- Fasting Mimicking Diet for Metabolic Syndrome: A Narrative Review of Human Studies.Metabolites · 2025Review
- Article
- Effects of seven days' fasting on physical performance and metabolic adaptation during exercise in humans.Nature communications · 2025Article
- Intermittent Fasting Sustainably Improves Glucose Tolerance in Normal Weight Male Mice Through Histone Hyperacetylation.Journal of the Endocrine Society · 2023Article
- The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets.Metabolites · 2022Article
- Effects of SGLT2 inhibition on lipid transport in adipose tissue in type 2 diabetes.Endocrine connections · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance is a well-known physiological adaptation to prolonged fasting in healthy skeletal muscle. Obesity is associated with insulin resistance and metabolic inflexibility in skeletal muscle, and a pronounced increase in the risk of metabolic complications. Under the hypothesis that the metabolic traits of insulin resistance associated with prolonged fasting are different from insulin resistance associated with obesity, we examined nine obese and nine lean participants during 12 and 72h of fasting, respectively. Insulin resistance in obese participants was associated with impaired insulin signaling, and reduced levels of glucose-6-phosphate and TCA-cycle intermediates. 72h of fasting in lean participants reduced insulin-stimulated glucose uptake to levels similar to obese participants fasted for 12h. This was associated with increased lipid oxidation, but not accumulation of diacylglycerol or acylcarnitines and impairment of insulin signaling. Prolonged fasting was associated with pronounced increases in β-hydroxybutyrate and β- hydroxybutyrylcarnitine levels in skeletal muscle suggesting augmented ketone body metabolism. Fasting induced insulin resistance may be a consequence of substrate competition. The underlying mechanism behind insulin resistance in obesity is thus not comparable to the physiological adaptations in skeletal muscle induced by prolonged fasting in lean participants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.