Evidence map›Paper›PMID 30183504›Full record

ArticleGut microbes2019

Epithelial maturity influences EPEC-induced desmosomal alterations.

Jennifer Lising Roxas, Gayatri Vedantam, V K Viswanathan

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jennifer Lising Roxasa School of Animal and Comparative Biomedical Sciences , University of Arizona , Tucson , AZ , USA.
Gayatri Vedantama School of Animal and Comparative Biomedical Sciences , University of Arizona , Tucson , AZ , USA.
V K Viswanathana School of Animal and Comparative Biomedical Sciences , University of Arizona , Tucson , AZ , USA.
University of Arizona · US

Funding

Dynamic Regulation of Epithelial Cell Survival by Enteropathogenic E. coliR01AI081742 · NIAID · UNIVERSITY OF ARIZONA · PI VISWANATHAN, V K · 2011 to 2015
$1.9M
Host-cell mitochondrial alterations play a central role in EPEC pathogenesisR01AI141626 · NIAID · UNIVERSITY OF ARIZONA · PI VISWANATHAN, V K · 2019 to 2023
$1.8M
NIAID NIH HHS R01 AI081742NIAID NIH HHS R01 AI141626
6 · The paper itself

Abstract

Desmosomes are junctional protein complexes that confer strong adhesive capacity to adjacent host cells. In a recent study, we showed that enteropathogenic Escherichia coli (EPEC) disrupts desmosomes, weakens cell-cell adhesion and perturbs barrier function of intestinal epithelial (C2

Indexed as

Cell AdhesionCell Line, TumorDesmoglein 2DesmosomesEnteropathogenic Escherichia coliEscherichia coli InfectionsHost-Pathogen InteractionsHumansIntestinal MucosaKeratinsDesmoglein 2KeratinsdesmogleindesmosomeDSG2EPECEspHkeratinRho GTPase

Identifiers

PMID30183504
PMCPMC6546310
OpenAlexW2892253116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.