Evidence map›Paper›PMID 30183294›Full record

ArticleJournal of medicinal chemistry2018

Structural Variants of a Liver Fluke Derived Granulin Peptide Potently Stimulate Wound Healing.

Mohadeseh Dastpeyman, Paramjit S Bansal, David Wilson, Javier Sotillo, Paul J Brindley, Alex Loukas, Michael J Smout, Norelle L Daly

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Glycogen Hydrogel Loaded withBiomolecules · 2026
    Article
  2. The C-terminal region ofAustralian journal of chemistry · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. American journal of translational research · 2021
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Hemozoin From the Liver Fluke,Frontiers in veterinary science · 2019
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Mohadeseh DastpeymanCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine , James Cook University , Cairns , QLD 4870 , Australia.
Paramjit S BansalCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine , James Cook University , Cairns , QLD 4870 , Australia.
David WilsonCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine , James Cook University , Cairns , QLD 4870 , Australia.
Javier SotilloCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine , James Cook University , Cairns , QLD 4870 , Australia.
Paul J BrindleyDepartment of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences , George Washington University , Washington, D.C. 20052 , United States.
Alex LoukasCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine , James Cook University , Cairns , QLD 4870 , Australia.
Michael J SmoutCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine , James Cook University , Cairns , QLD 4870 , Australia.ORCID 0000-0001-6937-0112
Norelle L DalyCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine , James Cook University , Cairns , QLD 4870 , Australia.ORCID 0000-0002-4697-6602
Australian Institute of Tropical Health and Medicine · AUGeorge Washington University · US

Funding

Targeting parasite-host communication to combat liver fluke-induced bile duct cancerR01CA164719 · NCI · GEORGE WASHINGTON UNIVERSITY · PI Paul J Brindley, THEWARACH LAHA · 2012 to 2026
$5.0M
NCI NIH HHS R01 CA164719
6 · The paper itself

Abstract

Granulins are a family of growth factors involved in cell proliferation. The liver-fluke granulin, Ov-GRN-1, isolated from a carcinogenic liver fluke Opisthorchis viverrini, can significantly accelerate wound repair in vivo and in vitro. However, it is difficult to express Ov-GRN-1 in recombinant form at high yield, impeding its utility as a drug lead. Previously we reported that a truncated analogue ( Ov-GRN

Indexed as

AnimalsCell ProliferationFasciola hepaticaFascioliasisFemaleGranulinsHelminth ProteinsMiceMice, Inbred BALB CPeptide FragmentsProtein ConformationSkin DiseasesWound HealingGranulinsHelminth ProteinsPeptide Fragments

Identifiers

PMID30183294
PMCPMC12212974
OpenAlexW2889607525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.