ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019
Hypercapnia increases brain viscoelasticity.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Mechanochemical regulation of organoid morphogenesis: Integrated signaling circuits in engineered microenvironments.Materials today. Bio · 2026Review
- Effects of intraoperative hypercapnia on postoperative brain functional network connectivity and cognitive function in adult patients undergoing Clipping Intracranial Aneurysm.BMC neurology · 2025Article
- Perfusion-mechanics coupling of the hippocampus.Interface focus · 2025Article
- Progress on the Effects of Permissive Hypercapnia on the CNS During the Intraoperative Period: A Narrative Review.Cureus · 2024Review
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Feasibility of assessing non-invasive intracranial compliance using FSI simulation-based and MR elastography-based brain stiffness.Scientific reports · 2024Article
- The contributions of relative brain viscosity to brain function and health.Brain communications · 2024Review
- Can magnetic resonance elastography serve as a diagnostic tool for gradual-onset brain disorders?Neurosurgical review · 2023Article
- Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Stiffness pulsation of the human brain detected by non-invasive time-harmonic elastography.Frontiers in bioengineering and biotechnology · 2023Article
- A framework of transient hypercapnia to achieve an increased cerebral blood flow induced by nasal breathing during aerobic exercise.Cerebral circulation - cognition and behavior · 2023Review
- Reply: A transvenous pressure gradient can explain the MR elastography findings in normal pressure hydrocephalus.Neurosurgical review · 2022Article
- Cerebral tomoelastography based on multifrequency MR elastography in two and three dimensions.Frontiers in bioengineering and biotechnology · 2022Article
- Cerebral stiffness changes during visual stimulation: Differential physiological mechanisms characterized by opposing mechanical effects.Neuroimage. Reports · 2021Article
- Hypercapnia in the critically ill: insights from the bench to the bedside.Interface focus · 2021Review
- Harnessing brain waves: a review of brain magnetic resonance elastography for clinicians and scientists entering the field.The British journal of radiology · 2021Review
- Simulating Local Deformations in the Human Cortex Due to Blood Flow-Induced Changes in Mechanical Tissue Properties: Impact on Functional Magnetic Resonance Imaging.Frontiers in neuroscience · 2021Article
- Real-Time Multifrequency MR Elastography of the Human Brain Reveals Rapid Changes in Viscoelasticity in Response to the Valsalva Maneuver.Frontiers in bioengineering and biotechnology · 2021Article
- Cardiac-gated steady-state multifrequency magnetic resonance elastography of the brain: Effect of cerebral arterial pulsation on brain viscoelasticity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Imaging brain function with simultaneous BOLD and viscoelasticity contrast: fMRI/fMRE.NeuroImage · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain function, the brain's metabolic activity, cerebral blood flow (CBF), and intracranial pressure are intimately linked within the tightly autoregulated regime of intracranial physiology in which the role of tissue viscoelasticity remains elusive. We applied multifrequency magnetic resonance elastography (MRE) paired with CBF measurements in 14 healthy subjects exposed to 5-min carbon dioxide-enriched breathing air to induce cerebral vasodilatation by hypercapnia. Stiffness and viscosity as quantified by the magnitude and phase angle of the complex shear modulus, |
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.