ArticleClinical EEG and neuroscience2019
Resting EEG Measures of Brain Arousal in a Multisite Study of Major Depression.
Article in Clinical EEG and neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01407094 (Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) for Depression
Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Arousal shapes motivation: an integrative framework for understanding motivational deficits.Translational psychiatry · 2026Review
- Arousal state alters brain network switching and moderates cognitive task performance.bioRxiv : the preprint server for biology · 2026Article
- Associations of physical activity, sedentary time, sleep quality, and resting EEG with mild depressive symptoms in college students: a cross-sectional study.BMC public health · 2025Article
- Cerebello-Prefrontal Connectivity Underlying Cognitive Dysfunction in Spinocerebellar Ataxia Type 2.Annals of clinical and translational neurology · 2025Article
- A case-control study on QEEG as a marker of cognition in depression.Indian journal of psychiatry · 2025Article
- Opportunities and Challenges for Clinical Practice in Detecting Depression Using EEG and Machine Learning.Sensors (Basel, Switzerland) · 2025Article
- Neurobiological Underpinnings of Hyperarousal in Depression: A Comprehensive Review.Brain sciences · 2024Review
- [Identifying Depressive Disorder With Sleep Electroencephalogram Data: A Study Based on Deep Learning].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
- The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD.Frontiers in psychiatry · 2023Article
- The biological dimensions of transcendent states: A randomized controlled trial.Frontiers in psychology · 2022Article
- Possible Effects of Bright Light Therapy on Electroencephalogram-Vigilance in the Treatment of Depression in Adolescents: A Pilot Study.Frontiers in psychiatry · 2022Article
- EEG Neurofeedback for Anxiety Disorders and Post-Traumatic Stress Disorders: A Blueprint for a Promising Brain-Based Therapy.Current psychiatry reports · 2021Review
- The Big Five Personality Traits and Brain Arousal in the Resting State.Brain sciences · 2021Article
- Structural brain measures linked to clinical phenotypes in major depression replicate across clinical centres.Molecular psychiatry · 2021Article
- Fatigue and brain arousal in patients with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2021Article
- Brain Arousal as Measured by EEG-Assessment Differs Between Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD) and Depression.Frontiers in psychiatry · 2021Article
- Increased behavioral inhibition trait and negative stress coping in non-rapid eye movement parasomnias.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Predicting Depression Symptoms in Families at Risk for Depression: Interrelations of Posterior EEG Alpha and Religion/Spirituality.Journal of affective disorders · 2020Article
- Fatigue in Cancer and Neuroinflammatory and Autoimmune Disease: CNS Arousal Matters.Brain sciences · 2020Article
- Prospective testing of a neurophysiologic biomarker for treatment decisions in major depressive disorder: The PRISE-MD trial.Journal of psychiatric research · 2020Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
Several studies have found upregulated brain arousal during 15-minute EEG recordings at rest in depressed patients. However, studies based on shorter EEG recording intervals are lacking. Here we aimed to compare measures of brain arousal obtained from 2-minute EEGs at rest under eyes-closed condition in depressed patients and healthy controls in a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). We expected that depressed patients would show stable and elevated brain arousal relative to controls. Eighty-seven depressed patients and 36 healthy controls from four research sites in the United States were included in the analyses. The Vigilance Algorithm Leipzig (VIGALL) was used for the fully automatic classification of EEG-vigilance stages (indicating arousal states) of 1-second EEG segments; VIGALL-derived measures of brain arousal were calculated. We found that depressed patients scored higher on arousal stability ( Z = -2.163, P = .015) and A stages (dominant alpha activity; P = .027) but lower on B1 stages (low-voltage non-alpha activity, P = .008) compared with healthy controls. No significant group differences were observed in Stage B2/3. In summary, we were able to demonstrate stable and elevated brain arousal during brief 2-minute recordings at rest in depressed patients. Results set the stage for examining the value of these measures for predicting clinical response to antidepressants in the entire EMBARC sample and evaluating whether an upregulated brain arousal is particularly characteristic for responders to antidepressants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.