Evidence map›Paper›PMID 30182359›Full record

Trial reportJournal of endocrinological investigation2019

Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis.

F Karimi, G R Omrani

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Selenium-enrichedFrontiers in fungal biology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The interplay between vitamin C and thyroid.Endocrinology, diabetes & metabolism · 2023
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. The Role of Selenium in Pathologies: An Updated Review.Antioxidants (Basel, Switzerland) · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

F KarimiDepartment of Internal Medicine, Endocrinology and Metabolism Research Center, Namazee Hospital, Shiraz University, Zand Street, Namazee Square, Shiraz, Iran. karimif2002@yahoo.com.ORCID http://orcid.org/0000-0002-6107-4826
G R OmraniDepartment of Internal Medicine, Endocrinology and Metabolism Research Center, Namazee Hospital, Shiraz University, Zand Street, Namazee Square, Shiraz, Iran.
Shiraz University · IR

Funding

Vice Chancellor for research of Shiraz University of medical Sciences 33-3100
6 · The paper itself

Abstract

purposeSelenium (Se), an essential trace element, has been implicated in pathogenesis of autoimmune thyroiditis (AIT). Most studies attributed the immune modulating effects of Se to its antioxidant properties. However, there is insufficient evidence to support the use of selenium supplementation or other antioxidants in patients with AIT. This clinical trial was designed to investigate the impact of Se and vitamin C supplementation on antithyroid peroxidase antibody (TPO-Ab) level in patients with AIT.

methodsOne hundred and two subjects aged 15-78 years were randomized into three groups. Group one (GI) (n = 38) was treated with 200 μg/day sodium selenite, group two (GII) (n = 36) received 500 mg vitamin C/day, and group three (GIII) (n = 28) received placebo over a 3-month period. Thyroid stimulating hormone (TSH), TPO-Ab, antithyroglobulin antibody (Tg-Ab) and Se concentrations were once measured before treatment and at the end of the study.

resultsAfter 3 months, TPO-Ab concentrations decreased within Se and vitamin C-treated groups, but did not change in the placebo subjects. In this regard, there was no significant difference between the groups. We also did not find any statistically significant difference in TSH and Tg-Ab levels within and between the groups. At the end of the study, Se level was significantly higher in GI compared with GII and GIII.

conclusionOur findings supported the hypothesis of antioxidant beneficial effects of Se in AIT. However, it was not superior to vitamin C, regarding its effects on thyroid-specific antibodies.

Indexed as

AdolescentAdultAgedAntioxidantsAscorbic AcidAutoantibodiesFemaleHumansIodide PeroxidaseMaleMiddle AgedProspective StudiesSeleniumSingle-Blind MethodThyroglobulinThyroiditis, AutoimmuneAntioxidantsAscorbic AcidAutoantibodiesIodide PeroxidaseSeleniumThyroglobulinthyroid microsomal antibodiesThyrotropinVitaminsAntithyroid peroxidase antibodyAutoimmune thyroiditisSeleniumVitamin C

Identifiers

PMID30182359
OpenAlexW2891917088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.