Evidence map›Paper›PMID 30182306›Full record

SynthesisSurgery today2019

Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review.

Haruki Sada, Takao Hinoi, Hideki Ueno, Tatsuro Yamaguchi, Yasuhiro Inoue, Tsuyoshi Konishi, Hirotoshi Kobayashi, Yukihide Kanemitsu, Fumio Ishida, Hideyuki Ishida and 3 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Surgery today, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Guideline
  3. Article
  4. Article
  5. Article
  6. Gastrointestinal Polyposis in Pediatric Patients.Journal of pediatric gastroenterology and nutrition · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Haruki SadaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Takao HinoiDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. thinoi@hiroshima-u.ac.jp.
Hideki UenoDepartment of Surgery, National Defense Medical College, Saitama, Japan.
Tatsuro YamaguchiDepartment of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Yasuhiro InoueDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Tsuyoshi KonishiGastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Hirotoshi KobayashiDepartment of Surgery, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.
Yukihide KanemitsuDivision of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Fumio IshidaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Hideyuki IshidaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Naohiro TomitaDivision of Lower GI Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Nagahide MatsubaraDivision of Lower GI Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Kenichi SugiharaTokyo Medical and Dental University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the recent Japanese prevalence of thyroid cancer and its characteristics in familial adenomatous polyposis (FAP) patients, through the development of surveillance programs.

methodsThe subjects of this study were 282 (93.1%) FAP patients for whom information on thyroid cancer was available, from among 303 patients registered in "the Retrospective Cohort Study of Familial Adenomatous Polyposis in Japan" database. We evaluated the prevalence and risk factors for thyroid cancer and integrated and/or compared our findings with those of previous reports, using a systematic review, including a meta-analysis.

resultsThyroid cancer was diagnosed in 16 women (11.4%) and 2 men (1.4%), at 17-41 years and 39-57 years of age, respectively. The prevalence of thyroid cancer was 6.4%, with a female-to-male ratio of 8:1, which is comparable to reports from other countries. A young age of < 33 years at the FAP diagnosis and female gender were identified as independent risk factors for thyroid cancer.

conclusionsFAP-associated thyroid cancer predominantly affects young women, both in Japan and other countries. Since FAP is generally diagnosed when patients are in their 20 s or older, regular screening for thyroid cancer is recommended for all FAP patients, but especially women, from their early 20 s.

Indexed as

Multicenter Studies as TopicAdenomatous Polyposis ColiAdolescentAdultAge FactorsFemaleHumansJapanMaleMiddle AgedPrevalenceRisk FactorsSex FactorsThyroid NeoplasmsYoung AdultFamilial adenomatous polyposisMeta-analysisPrevalenceRisk factorThyroid cancer

Identifiers

PMID30182306

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.