ArticleInternational urology and nephrology2018
Both insulin resistance and metabolic syndrome accelerate the progression of chronic kidney disease among Chinese adults: results from a 3-year follow-up study.
Article in International urology and nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Psoriasis and chronic kidney disease: insights into mechanisms and novel therapeutic outlooks.International urology and nephrology · 2026Review
- Relevance of Kidney-Metabolic Multimorbidity Pattern to Metabolic Health and Mortality Among Elderly Inpatients in China.Food science & nutrition · 2026Article
- Article
- Association of metabolic syndrome and hyperuricemia with mortality in patients with chronic kidney disease: a UK biobank study.BMC nephrology · 2025Article
- Prevalence of metabolic syndrome in people living with HIV and its multi-organ damage: a prospective cohort study.BMC infectious diseases · 2025Article
- Chronic kidney disease combined with metabolic syndrome is a non-negligible risk factor.Therapeutic advances in endocrinology and metabolism · 2024Review
- The association between liver fibrosis scores and chronic kidney disease.Frontiers in medicine · 2023Article
- Glucose Metabolism Indices and the Development of Chronic Kidney Disease: A Cohort Study of Middle-Aged and Elderly Chinese Persons.International journal of endocrinology · 2023Article
- Article
- Metabolic Syndrome-Related Kidney Injury: A Review and Update.Frontiers in endocrinology · 2022Review
- Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review.Nutrients · 2021Review
- Article
- The emerging role of dyslipidemia in diabetic microvascular complications.Current opinion in endocrinology, diabetes, and obesity · 2020Review
- Poor Control of Plasma Triglycerides Is Associated with Early Decline of Estimated Glomerular Filtration Rates in New-Onset Type 2 Diabetes in China: Results from a 3-Year Follow-Up Study.Journal of diabetes research · 2020Article
- Association between Heavy Metals, Bisphenol A, Volatile Organic Compounds and Phthalates and Metabolic Syndrome.International journal of environmental research and public health · 2019Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMetabolic syndrome (MetS) has been found to be associated with an increased risk for chronic kidney disease (CKD). However, the relationship between insulin resistance (IR), which is believed to play a central role in the pathogenesis of MetS, and CKD is still unclear in Chinese adults and needs further investigation.
methodsThis 3-year follow-up study included 3237 middle-aged and elderly Chinese without CKD at baseline. Estimated glomerular filtration rate (eGFR) 60-90 mL/min/1.73 m
resultsThe incidences of CKD and mildly reduced eGFR for the entire cohort were 20.08 and 33.28 per 1000 person-years, respectively. A large proportion [13.1% (182/1394)] of patients with mildly reduced eGFR progressed to CKD in 3 years. After accounting for age, gender, five components of MetS and HOMA-IR in multiple logistic regression model, only IR presented increased OR (1.119, 95% CI 1.052-1.189, p < 0.001) for CKD. When we included MetS instead of its five components in model, both MetS (OR 1.420, 95% CI 1.020-1.977, p = 0.038) and HOMA-IR (OR 1.118, 95% CI 1.055-1.186, p < 0.001) showed increased risk for CKD progression.
conclusionsBoth IR and MetS accelerate the progression of CKD among Chinese adults. Single metabolic abnormality did not have enough potency to induce the occurrence of CKD in 3 years.
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