Evidence map›Paper›PMID 30182188›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2019

Atorvastatin ameliorates the contractile dysfunction of the aorta induced by organ culture.

Feng Zhou, Fang Rao, You-Qing Deng, Hui Yang, Su-Juan Kuang, Fei-Long Wu, Shu-Lin Wu, Yu-Mei Xue, Xiao-Mu Wu, Chun-Yu Deng

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Feng ZhouDepartment of Neurology, The Third Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Fang RaoDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangzhou, China.ORCID 0000-0002-1181-2333
You-Qing DengDepartment of Neurology, The Third Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Hui YangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangzhou, China.
Su-Juan KuangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangzhou, China.
Fei-Long WuDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangzhou, China.
Shu-Lin WuDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangzhou, China.
Yu-Mei XueDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangzhou, China.
Xiao-Mu WuDepartment of Neurology, Jiangxi Provincial People's Hospital, 92 Aiguo Road, Nanchang, 330000, People's Republic of China. wuxm79@163.com.
Chun-Yu DengDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangzhou, China. chunyudeng@126.com.
Guangdong General Hospital · CNNanchang University · CNJiangxi Provincial People's Hospital · CN

Funding

Guangdong Provincial medical science foundation A2015229National Natural Science Foundation of China 81273516National Natural Science Foundation of China 81302779National Natural Science Foundation of China 81370295National Natural Science Foundation of China 81470440
6 · The paper itself

Abstract

Statins are widely used in the treatment of hypercholesterolemia. Studies have demonstrated that statins could maintain vascular contractile function through inhibiting the transformation of vascular smooth muscle cells (VSMCs) from the contractile phenotype to the synthetic phenotype. However, the underlying mechanisms have not been fully elucidated. The effect of atorvastatin on the thoracic aorta of Sprague-Dawley rats cultured in serum-free conditions in vitro was evaluated. Aortic constriction was induced by high potassium, phenylephrine, and CaCl

Indexed as

ActinsAnimalsAorta, ThoracicAtorvastatinCalcium Channels, L-TypeHydroxymethylglutaryl-CoA Reductase InhibitorsInositol 1,4,5-Trisphosphate ReceptorsMaleMyosinsOrgan Culture TechniquesProtein Kinase C-deltaRats, Sprague-DawleyReceptors, Adrenergic, alpha-1Stromal Interaction Molecule 1VasoconstrictionActa2 protein, ratActinsAtorvastatinCalcium Channels, L-TypeHydroxymethylglutaryl-CoA Reductase InhibitorsInositol 1,4,5-Trisphosphate ReceptorsL-type calcium channel alpha(1C)MyosinsPrkcd protein, ratProtein Kinase C-deltaReceptors, Adrenergic, alpha-1Stim1 protein, ratStromal Interaction Molecule 1AortaAtorvastatinCalcium handlingOrgan cultureα1 adrenoceptor

Identifiers

PMID30182188
OpenAlexW2892034190

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.