Evidence map›Paper›PMID 30182166›Full record

ArticleHepatology international2019

Serum ferritin level is associated with liver steatosis and fibrosis in Korean general population.

Ju Young Jung, Jae-Jun Shim, Sung Keun Park, Jae-Hong Ryoo, Joong-Myung Choi, In-Hwan Oh, Kyu-Won Jung, Hyunsoon Cho, Moran Ki, Young-Joo Won and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Hepatology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Serum Ferritin and Non-alcoholic Fatty Liver Disease: A Meta-analysis and Systematic Review.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
    Pooled it
  4. Guideline
  5. Trial
  6. Review
  7. Observational
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ju Young JungTotal Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
Jae-Jun ShimDepartments of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Sung Keun ParkTotal Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
Jae-Hong RyooDepartments of Occupation and Environmental medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Joong-Myung ChoiDepartments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
In-Hwan OhDepartments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Kyu-Won JungCancer Registration and Statistic Branch, National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea.
Hyunsoon ChoCancer Registration and Statistic Branch, National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea.
Moran KiDepartment of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea.
Young-Joo WonCancer Registration and Statistic Branch, National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea.
Chang-Mo OhDepartments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. kachas@naver.com.ORCID http://orcid.org/0000-0002-5709-9350
Kyung Hee University · KRNational Cancer Center · KRKangbuk Samsung Hospital · KR

Funding

Kyung Hee University KHU-20170835National Cancer Center NCC-1610170
6 · The paper itself

Abstract

backgroundElevation of serum ferritin levels is frequently observed in non-alcoholic fatty liver disease (NAFLD) patients. Our study aims to examine the association between serum ferritin levels and NAFLD in Korean population. METHODS AND

resultsA total of 25,597 participants were selected from Korean National Health and Nutritional Examination Surveys 2007-2012. The NAFLD liver fat score (NLFS) was used to define NAFLD. Elevation of ALT levels was defined as ALT level > 40 IU/L for male and ALT level > 31 IU/L for female. Multiple logistic regression was used to examine the association of serum ferritin levels and NAFLD by sex. After adjusting for multiple covariates, the ORs (95% CI) of the elevated ALT levels were 1.56 (95% CI: 1.17-2.07), 1.84 (95% CI: 1.39-2.45), and 4.08 (95% CI: 3.08-5.40) for the second, third and fourth serum ferritin quartiles in male (p for trend < 0.01), 1.67 (95% CI: 1.24-2.23), 2.23 (95% CI: 1.68-2.96), and 5.72 (95% CI: 4.32-7.60) for the second, third and fourth serum ferritin quartiles in female (p for trend < 0.01). Serum ferritin levels were also significantly associated with NAFLD and liver fibrosis both in male and female.

conclusionsElevation of serum ferritin level is significantly associated with NAFLD and blood ALT elevation in Korean general population.

Indexed as

AdultAlanine TransaminaseAspartate AminotransferasesFemaleFerritinsgamma-GlutamyltransferaseHumansLiver CirrhosisMaleNon-alcoholic Fatty Liver DiseaseNutrition SurveysRepublic of KoreaYoung AdultAlanine TransaminaseAspartate AminotransferasesFerritinsgamma-GlutamyltransferaseAlanine aminotransferaseIronNon-alcoholic fatty liver disease

Identifiers

PMID30182166
OpenAlexW2891362974

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.