Evidence map›Paper›PMID 30182154›Full record

ArticleLung2018

Annexin A5 Protein as a Potential Biomarker for the Diagnosis of Asthma.

Sun-Hye Lee, Pureun-Haneul Lee, Byeong-Gon Kim, Jisu Hong, An-Soo Jang

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Olfactomedin 4 as a circulating biomarker for asthma.Annals of translational medicine · 2022
    Article
  7. Article
  8. Current Insights on the Impact of Proteomics in Respiratory Allergies.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Article
  11. Reduced Annexin A3 in schizophrenia.European archives of psychiatry and clinical neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sun-Hye LeeDivision of Respiratory and Allergy, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 14584, Republic of Korea.
Pureun-Haneul LeeDivision of Respiratory and Allergy, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 14584, Republic of Korea.
Byeong-Gon KimDivision of Respiratory and Allergy, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 14584, Republic of Korea.
Jisu HongDivision of Respiratory and Allergy, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 14584, Republic of Korea.
An-Soo JangDivision of Respiratory and Allergy, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 14584, Republic of Korea. jas877@schmc.ac.kr.ORCID http://orcid.org/0000-0002-3052-0571
Soonchunhyang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnnexin A5 (ANXA5) has a potential role in cellular signal transduction, inflammation, and fibrosis. However, the exact role of ANXA5 in asthma remains to be clarified. The aims of the present study were to investigate ANXA5 protein expression in a mouse model of asthma and pollutant exposure and to elucidate the relationships between clinical variables and plasma ANXA5 levels in patients with asthma.

methodsA murine model of asthma induced by ovalbumin (OVA) and titanium dioxide (TiO

resultsANXA5 protein levels were lower in lung tissue from OVA + OVA mice than in control mice. Lung ANXA5, connective tissue growth factor (CTGF), and transforming growth factor β1 (TGF-β1) protein levels were higher in OVA + TiO

conclusionOur results imply that ANXA5 plays a potential role in asthma pathogenesis and may be a promising marker for exacerbated bronchial asthma and exposure to air pollutants.

Indexed as

A549 CellsAgedAir PollutantsAnimalsAnnexin A5Antigens, DermatophagoidesAsthmaBiomarkersConnective Tissue Growth FactorDermatophagoides pteronyssinusDisease Models, AnimalDisease ProgressionFemaleForced Expiratory VolumeHumansMaleAir PollutantsAnnexin A5Antigens, DermatophagoidesANXA5 protein, humanAnxa5 protein, mouseBiomarkersCCN2 protein, mouseConnective Tissue Growth FactorOvalbuminTgfb1 protein, mouseTitaniumtitanium dioxideTransforming Growth Factor beta1Annexin A5AsthmaEpithelial cellsFibroblastsPlasma

Identifiers

PMID30182154
OpenAlexW2891508063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.