Evidence map›Paper›PMID 30182051›Full record

ArticleCellular and molecular gastroenterology and hepatology2018

Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.

Brie K Fuqua, Yan Lu, David M Frazer, Deepak Darshan, Sarah J Wilkins, Linda Dunn, Alex V Loguinov, Scott C Kogan, Pavle Matak, Huijun Chen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Iron from the gut: the role of divalent metal transporter 1.Journal of clinical biochemistry and nutrition · 2024
    Article
  6. Article
  7. The biology of mammalian multi-copper ferroxidases.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Review
  8. Article
  9. Review
  10. Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Iron and manganese transport in mammalian systems.Biochimica et biophysica acta. Molecular cell research · 2021
    Review
  16. HFrontiers in medicine · 2021
    Article
  17. Iron Metabolism in Cancer Progression.International journal of molecular sciences · 2020
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Brie K FuquaDepartment of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, California.
Yan LuIron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
David M FrazerIron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Deepak DarshanIron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Sarah J WilkinsIron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Linda DunnIron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Alex V LoguinovDepartment of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, California.
Scott C KoganDepartment of Laboratory Medicine and Helen Diller Comprehensive Cancer Center and Mouse Pathology Core, University of California, San Francisco, California.
Pavle MatakDepartment of Pharmacology and Cancer Biology, Duke University, Duke University Medical Center, Durham, North Carolina.
Huijun ChenMedical School, Nanjing University, Nanjing, Jiangsu Province, China.
Joshua L DunaiefFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania.
Chris D VulpeDepartment of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, California.
Gregory J AndersonIron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
QIMR Berghofer Medical Research Institute · AUUniversity of California, Berkeley · USDuke Medical Center · USNanjing Medical University · CNUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of Pennsylvania · USUniversity of Queensland · AU

Funding

Retinal Iron Transport in Health and DiseaseR01EY015240 · NEI · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA L DUNAIEF · 2004 to 2026
$10.4M
An integrated molecular approach to understand variation in iron metabolismR01GM083198 · NIGMS · UNIVERSITY OF FLORIDA · PI VULPE, CHRISTOPHER D · 2012 to 2015
$2.7M
NEI NIH HHS R01 EY015240NIGMS NIH HHS R01 GM083198
6 · The paper itself

Abstract

Background & Aims: Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe Methods: Mice lacking both HEPH and CP ( Results: Conclusions: These studies indicate that HEPH and CP, and likely MCFs in general, are not essential for intestinal iron absorption but are required for proper systemic iron distribution. They also point to important extra-intestinal roles for HEPH in maintaining whole-body iron homeostasis.

Indexed as

Absorption, PhysiologicalAnemiaAnimalsAnimals, SucklingBody SizeBody WeightCation Transport ProteinsCeruloplasminDisease Models, AnimalDuodenumEnterocytesFemaleFerroportinIronLigationMaleCation Transport ProteinsCeruloplasminFerroportinHeph protein, mouseIronMembrane ProteinsCP, ceruloplasminCp-/-, mice lacking CP in the whole bodyDAB, 3,3′-diaminobenzidineFDR, false discovery rateFPN1, ferroportin 1GI, gastrointestinalHCI, hydrochloric acidHeph-/-Cp-/- or DKO, double-knockout mice lacking both HEPH and CPHephfl/flCp-/-, mice with floxed Heph alleles and lacking CP in the whole bodyHephfl/fl, mice with floxed Heph allelesHEPH, hephaestinHephint/intCp-/-, mice lacking HEPH in the intestine alone and lacking CP in the whole bodyHephint/int, mice lacking HEPH in the intestine aloneHeph-/-, mice lacking HEPH in the whole bodyHephsla/slaCp-/-, mice lacking CP in the whole body and expressing only the sla mutant form of HEPHIntestinal Iron AbsorptionIron Deficiency AnemiaIron OverloadMCF, multicopper ferroxidaseNon-Transferrin Bound IronNTBI, non-transferrin bound ironPBS, phosphate-buffered salinePCR, polymerase chain reactionSD, standard deviationsla, sex-linked anemiaTBST, Tris-buffered saline with 0.1% Tween-20TF, transferrinTIBC, total iron binding capacityWT, wild-type

Identifiers

PMID30182051
PMCPMC6120670
OpenAlexW2811471978

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.