Evidence map›Paper›PMID 30182030›Full record

ArticleOpen forum infectious diseases2018

HIV Testing After a First Positive Rapid Diagnostic Test: A Role for Nucleic Acid Testing?

Anne M Neilan, Jennifer E Cohn, Jean-Francois Lemaire, Emma Sacks, Rebecca Alban, Kenneth A Freedberg, Rochelle P Walensky, Andrea L Ciaranello

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Nucleic acid amplification testing using dried blood spots to confirm the diagnosis of HIV-1 in adults.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anne M NeilanDivision of Infectious Diseases and Medical Practice Evaluation Center, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-7915-4974
Jennifer E CohnElizabeth Glaser Pediatric AIDS Foundation, Geneva, Switzerland.
Jean-Francois LemaireElizabeth Glaser Pediatric AIDS Foundation, Geneva, Switzerland.
Emma SacksElizabeth Glaser Pediatric AIDS Foundation, Geneva, Switzerland.
Rebecca AlbanElizabeth Glaser Pediatric AIDS Foundation, Geneva, Switzerland.
Kenneth A FreedbergDivision of Infectious Diseases and Medical Practice Evaluation Center, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts.
Rochelle P WalenskyDivision of Infectious Diseases and Medical Practice Evaluation Center, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts.
Andrea L CiaranelloDivision of Infectious Diseases and Medical Practice Evaluation Center, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts.

Funding

LOC-IMPAACT Leadership GroupPharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant Women in the USUM1AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI Sharon A Nachman · 2011 to 2026
$278.1M
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Optimizing HIV Care in Less Developed CountriesR01AI058736 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Emily Parker Hyle · 2004 to 2026
$21.5M
Innovation across the spectrum of pediatric HIV care: Clinical impact and cost-effectiveness of long-acting antiretroviral therapy for breastfeeding people with HIV and their infants in ZimbabweR01HD079214 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI CIARANELLO, ANDREA LYNNE · 2014 to 2023
$8.0M
Novel Methods to Inform HIV/TB Clinical Trial DevelopmentR01AI093269 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI REDDY, KRISHNA P · 2011 to 2024
$6.8M
Optimizing HIV Care in Less Developed CountriesR37AI058736 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI FREEDBERG, KENNETH ALAN · 2018 to 2024
$6.6M
Novel Methods to Inform HIV/TB Clinical Trial DevelopmentR37AI093269 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WALENSKY, ROCHELLE P. · 2015 to 2019
$3.8M
NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI058736NIAID NIH HHS R01 AI093269NIAID NIH HHS R37 AI093269NIAID NIH HHS UM1 AI068632NICHD NIH HHS R01 HD079214
6 · The paper itself

Abstract

We developed an open-access, Excel-based model simulating currently recommended and alternative algorithms for adult HIV testing as a preliminary investigation of trade-offs between accuracy and costs. Despite higher costs, simpler HIV testing algorithms incorporating point of care nucleic acid testing may improve outcomes and thus merit additional research and field testing.

Indexed as

accuracycostshuman immunodeficiency virusnucleic acid testsrapid diagnostic tests

Identifiers

PMID30182030
PMCPMC6114195

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.