Evidence map›Paper›PMID 30181904›Full record

ArticleInternational journal of retina and vitreous2018

Clinical course of acute zonal occult outer retinopathy complicated by choroidal neovascularization.

Ugo Introini, Giuseppe Casalino, Elona Dhrami-Gavazi, Sri Krishna Mukkamala, Sarah Mrejen, Hermann Schubert, Salomon Y Cohen, Claudio Azzolini, Francesco Bandello, Stanley Chang and 1 more

Abstract read
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In one paragraph

Article in International journal of retina and vitreous, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ugo Introini1Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.
Giuseppe Casalino1Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.
Elona Dhrami-GavaziVitreous Retina Macula Consultants of New York, New York, USA.
Sri Krishna MukkamalaVitreous Retina Macula Consultants of New York, New York, USA.
Sarah MrejenOphthalmic Center for Imaging and Laser, Paris, France.
Hermann Schubert4Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, USA.
Salomon Y CohenOphthalmic Center for Imaging and Laser, Paris, France.
Claudio Azzolini6Department of Surgical Sciences, Ophthalmology Section, University of Insubria Ospedale di Circolo, Varèse, Italy.
Francesco Bandello1Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.
Stanley Chang4Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, USA.
Lawrence A YannuzziVitreous Retina Macula Consultants of New York, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report the clinical course and multimodal imaging features of acute zonal occult outer retinopathy (AZOOR) complicated by choroidal neovascularization (CNV) treated with anti-vascular endothelial growth factor (VEGF) treatment or photodynamic therapy (PDT).

methodsObservational case series. Retrospective analysis of patients presenting to different institutions with evidence of AZOOR and neovascular lesions. Diagnosis of AZOOR was made on the basis of clinical presentation and multimodal imaging. All patients underwent a comprehensive ophthalmic evaluation and multimodal retinal imaging, including color fundus photos, fundus autofluorescence, fundus fluorescein angiography and spectral-domain optical coherence tomography.

resultsFour patients (three males, mean age 53.5 years) were included in the study. Mean follow-up was 5.1 years. Presentation of AZOOR was unilateral in two patients and bilateral in the remainder two patients. One of the patients presenting with unilateral AZOOR developed zonal lesions in the fellow eye during follow-up. All patients presented with unilateral type 2 (subretinal) CNV. Three patients underwent intravitreal anti-VEGF injections and one patient underwent a single PDT. Multimodal retinal imaging showed zonal or multizonal progression during treatment. After treatment, visual acuity and CNV stabilization was observed in all patients.

conclusionsThe presence of CNV expands the clinical spectrum of AZOOR. CNV complicating AZOOR may be effectively treated with intravitreal injections of anti-VEGF, despite progression of the zonal lesions. Further studies are required to define the role of treatment in the progression of the zonal lesions.

Indexed as

Acute zonal occult outer retinopathyAnti-vascular endothelial growth factor treatmentChoroidal neovascularizationMultimodal retinal imaging

Identifiers

PMID30181904
PMCPMC6114516

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.