ArticleTherapeutic advances in drug safety2018
Shed-MEDS: pilot of a patient-centered deprescribing framework reduces medications in hospitalized older adults being transferred to inpatient postacute care.
Article in Therapeutic advances in drug safety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Why do older adults decline participation in research? Results from two deprescribing clinical trials.Trials · 2023Trial
- Deprescribing Medications Among Older Adults From End of Hospitalization Through Postacute Care: A Shed-MEDS Randomized Clinical Trial.JAMA internal medicine · 2023Trial
- Communication and Medication-Related Deprescribing for Healthcare Professionals: A Rapid Review of the Literature.Worldviews on evidence-based nursing · 2026Review
- Potentially inappropriate prescriptions in acutely admitted older patients: a development study to create a clinical decision support tool using a Delphi process.European geriatric medicine · 2026Article
- The Barriers to Deprescription in Older Patients: A Survey of Spanish Clinicians.Healthcare (Basel, Switzerland) · 2023Article
- Why do Older Adults Decline Participation in Research? Results from Two Deprescribing Clinical Trials.Research square · 2023Article
- Article
- Challenges and opportunities in creating a deprescribing program in the emergency department: A qualitative study.Journal of the American Geriatrics Society · 2023Article
- Feasibility of the Implementation of LESS-CHRON in Clinical Practice: A Pilot Intervention Study in Older Patients With Multimorbidity.Innovation in aging · 2023Article
- Optimising a person-centred approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: a realist review.BMC medicine · 2022Review
- Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis.Health technology assessment (Winchester, England) · 2022Review
- Care coordination needs for deprescribing benzodiazepines and benzodiazepine receptor agonists.Research in social & administrative pharmacy : RSAP · 2022Article
- Improving medication adherence and effective prescribing through a patient-centered prescription model in patients with multimorbidity.European journal of clinical pharmacology · 2022Article
- The role of older patients' goals in GP decision-making about medicines: a qualitative study.BMC family practice · 2021Article
- Using Deprescribing Practices and the Screening Tool of Older Persons' Potentially Inappropriate Prescriptions Criteria to Reduce Harm and Preventable Adverse Drug Events in Older Adults.Journal of patient safety · 2020Article
- Development and Validation of Nine Deprescribing Algorithms for Patients on Hemodialysis to Decrease Polypharmacy.Canadian journal of kidney health and disease · 2020Article
- Utilisation of medications among elderly patients in intensive care units: a cross-sectional study using a nationwide claims database.BMJ open · 2019Article
- A patient-centered deprescribing intervention for hospitalized older patients with polypharmacy: rationale and design of the Shed-MEDS randomized controlled trial.BMC health services research · 2019Article
- Foreword to the first special collection: Addressing the invisible iatrogenic epidemic: the role of deprescribing in polypharmacy and inappropriate medication use.Therapeutic advances in drug safety · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPolypharmacy is common in hospitalized older adults. Deprescribing interventions are not well described in the acute-care setting. The objective of this study was to describe a hospital-based, patient-centered deprescribing protocol (Shed-MEDS) and report pilot results.
methodsThis was a pilot study set in one academic medical center in the United States. Participants consisted of a convenience sample of 40 Medicare-eligible, hospitalized patients with at least five prescribed medications. A deprescribing protocol (Shed-MEDS) was implemented among 20 intervention and 20 usual care control patients during their hospital stay. The primary outcome was the total number of medications deprescribed from hospital enrollment. Deprescribed was defined as medication termination or dose reduction. Enrollment medications reflected all prehospital medications and active in-hospital medications. Baseline characteristics and outcomes were compared between the intervention and usual care groups using simple logistic or linear regression for categorical and continuous measures, respectively.
resultsThere was no significant difference between groups in mean age, sex or Charlson comorbidity index. The intervention and control groups had a comparable number of medications at enrollment, 25.2 (±6.3) and 23.4 (±3.8), respectively. The number of prehospital medications in each group was 13.3 (±4.6) and 15.3 (±4.6), respectively. The Shed-MEDS protocol compared with usual care significantly increased the mean number of deprescribed medications at hospital discharge and reduced the total medication burden by 11.6
conclusionsA hospital-based, patient-centered deprescribing intervention is feasible and may reduce the medication burden in older adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.