Evidence map›Paper›PMID 30181812›Full record

ArticleOncotarget2018

Accelerated

Delphine Serre, Julia Salleron, Marie Husson, Agnès Leroux, Pauline Gilson, Jean-Louis Merlin, Lionnel Geoffrois, Alexandre Harlé

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Evaluation of the Idylla IDH1-2 Mutation Assay for the Detection ofInternational journal of molecular sciences · 2026
    Article
  2. Comparison of Two Rapid Assays for the Detection ofDiagnostics (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Delphine SerreInstitut de Cancérologie de Lorraine, Département d'Oncologie Médicale, Vandoeuvre-lès-Nancy Cedex 54519, France.
Julia SalleronInstitut de Cancérologie de Lorraine, Cellule Data Biostatistiques, Vandoeuvre-lès-Nancy Cedex 54519, France.
Marie HussonInstitut de Cancérologie de Lorraine, Biopathologie, Vandoeuvre-lès-Nancy Cedex 54519, France.
Agnès LerouxUniversité de Lorraine, CNRS UMR 7039 CRAN, Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy Cedex 54519, France.
Pauline GilsonUniversité de Lorraine, CNRS UMR 7039 CRAN, Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy Cedex 54519, France.
Jean-Louis MerlinUniversité de Lorraine, CNRS UMR 7039 CRAN, Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy Cedex 54519, France.
Lionnel GeoffroisInstitut de Cancérologie de Lorraine, Département d'Oncologie Médicale, Vandoeuvre-lès-Nancy Cedex 54519, France.
Alexandre HarléUniversité de Lorraine, CNRS UMR 7039 CRAN, Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy Cedex 54519, France.
Centre National de la Recherche Scientifique · FRInstitut de Cancérologie de Lorraine · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDetermination of BRAF status is important for the therapeutic management of patients with metastatic melanoma.

objectivesWe evaluated the impact of a faster determination of BRAF mutational status on the delay between initial consultation and initiation of treatment.

resultsFor the FA-PCR group a median delay of 16 days [11;18] was observed between initial consultation and the implementation of treatment, which was significantly lower than that observed for the SOP group (26 days [20;46],

conclusionsIn comparison to using conventional SOP, using an FA-PCR platform for BRAF mutation analysis of patients with metastatic melanoma significantly reduced the delay in initiation of personalized therapy by 10 days. MATERIALS AND

methodsAnalysis of the BRAF mutation status of eight formalin-fixed paraffin-embedded (FFPE) tissue samples was performed using a CE-IVD fully-automated (FA) PCR-based platform. The delay between initial consultation and the implementation of treatment was compared between these samples (FA-PCR group) and a retrospective group of 29 FFPE samples analysed by standard operating procedures (SOP group) using conventional PCR.

Indexed as

automated real-time PCRBRAFmetastatic melanomatherapeutic management

Identifiers

PMID30181812
PMCPMC6114952
OpenAlexW2887316900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.