Evidence map›Paper›PMID 30181737›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2018

Pharmacological characterization of cnidarian extracts from the Caribbean Sea: evaluation of anti-snake venom and antitumor properties.

Cláudia S Oliveira, Cleópatra A S Caldeira, Rafaela Diniz-Sousa, Dolores L Romero, Silvana Marcussi, Laura A Moura, André L Fuly, Cicília de Carvalho, Walter L G Cavalcante, Márcia Gallacci and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. New multienzymatic complex formed between human cathepsin D and snake venom phospholipase AThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  3. Identification of a pore-forming protein from sea anemoneThe journal of venomous animals and toxins including tropical diseases · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Cláudia S OliveiraCentro de Estudos de Biomoléculas Aplicadas a Saúde (CEBio), Fundação Oswaldo Cruz de Rondônia (Fiocruz Rondônia), Porto Velho, RO Brazil.
Cleópatra A S CaldeiraCentro de Estudos de Biomoléculas Aplicadas a Saúde (CEBio), Fundação Oswaldo Cruz de Rondônia (Fiocruz Rondônia), Porto Velho, RO Brazil.
Rafaela Diniz-SousaCentro de Estudos de Biomoléculas Aplicadas a Saúde (CEBio), Fundação Oswaldo Cruz de Rondônia (Fiocruz Rondônia), Porto Velho, RO Brazil.
Dolores L Romero4Centro de Estudios de Proteínas, Facultad de Biología, Universidad de La Habana, Havana, Cuba.
Silvana Marcussi5Departamento de Química, Universidade Federal de Lavras (UFLA), Lavras, MG Brazil.
Laura A Moura6Departamento de Biologia Celular e Molecular (GCM), Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói, RJ Brazil.
André L Fuly6Departamento de Biologia Celular e Molecular (GCM), Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói, RJ Brazil.
Cicília de Carvalho7Departamento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, SP Brazil.
Walter L G Cavalcante7Departamento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, SP Brazil.
Márcia Gallacci7Departamento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, SP Brazil.
Maeli Dal Pai9Departamento de Morfologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, SP Brazil.
Juliana P ZulianiCentro de Estudos de Biomoléculas Aplicadas a Saúde (CEBio), Fundação Oswaldo Cruz de Rondônia (Fiocruz Rondônia), Porto Velho, RO Brazil.
Leonardo A CalderonCentro de Estudos de Biomoléculas Aplicadas a Saúde (CEBio), Fundação Oswaldo Cruz de Rondônia (Fiocruz Rondônia), Porto Velho, RO Brazil.
Andreimar M SoaresCentro de Estudos de Biomoléculas Aplicadas a Saúde (CEBio), Fundação Oswaldo Cruz de Rondônia (Fiocruz Rondônia), Porto Velho, RO Brazil.
Universidade Estadual Paulista (Unesp) · BRBiotech (Brazil) · BRCentro de Excelência em Bioinformática · BRUniversidade Federal Fluminense · BRUniversidade Federal de Lavras · BRUniversidade Federal de Rondônia · BRUniversity of Havana · CU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCnidarians produce toxins, which are composed of different polypeptides that induce pharmacological effects of biotechnological interest, such as antitumor, antiophidic and anti-clotting activities. This study aimed to evaluate toxicological activities and potential as antitumor and antiophidic agents contained in total extracts from five cnidarians:

methodsThe cnidarian extracts were evaluated by electrophoresis and for their phospholipase, proteolytic, hemorrhagic, coagulant, fibrinogenolytic, neuromuscular blocking, muscle-damaging, edema-inducing and cytotoxic activities.

resultsAll cnidarian extracts showed indirect hemolytic activity, but only

conclusionThe cnidarian extracts analyzed showed relevant in vitro inhibitory potential over the activities induced by Bothrops venoms; these results may contribute to elucidate the possible mechanisms of interaction between cnidarian extracts and snake venoms.

Indexed as

AntiophidicAntitumorBioprospectionCaribbean sea cnidariansNatural products

Identifiers

PMID30181737
PMCPMC6114500
OpenAlexW2888853908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.