Evidence map›Paper›PMID 30181729›Full record

ArticleDose-response : a publication of International Hormesis Society

The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid-Coated Gold Nanorods.

Su Pan, Hongcun Xing, Xuqi Fu, Hongmei Yu, Zhaogang Yang, Yudan Yang, Wei Sun

Open access · goldAbstract read
In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Macrophage Repolarization as a Therapeutic Strategy for Osteosarcoma.International journal of molecular sciences · 2023
    Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Cellular Toxicity Study of Silicon Nanowires.Dose-response : a publication of International Hormesis Society
    Article
  8. Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology.Dose-response : a publication of International Hormesis Society
    Article
  9. Article
  10. Targeting Approaches of Nanomedicines in Acute Myeloid Leukemia.Dose-response : a publication of International Hormesis Society
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Su PanDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin, China.
Hongcun XingCollege of Life Sciences, Jilin University, Changchun, Jilin, China.
Xuqi FuCollege of Life Sciences, Jilin University, Changchun, Jilin, China.
Hongmei YuChina-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Zhaogang YangDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.
Yudan YangChina-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Wei SunDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China.
Jilin University · CNSecond Affiliated Hospital of Jilin University · CNThe Ohio State University · USUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolyacrylic acid (PAA)-coated gold nanorods (GNRs) were prepared in this research, and then the structure, stability, temperature increment efficiency, and biocompatibility of GNRs@PAA were detected.

methodsIt was demonstrated that GNRs@PAA coupled with an 808 nm laser had superior efficiency of hyperthermia therapy for MG63 human osteosarcoma cell.

resultsThe mechanism of photothermal therapy of GNRs@PAA was explored, and it was proved that damaged cell membrane and DNA integration caused cell apoptosis and death, and the cell apoptosis rate had been obviously promoted by in vitro photothermal therapy which exhibited time-dose dependence.

conclusionThe results demonstrated that the GNRs@PAA could be a promising candidate for phototherapeutic applications in human osteosarcoma.

Indexed as

apoptosismetal nanostructuresosteosarcomaphotothermal therapytime–dose dependent

Identifiers

PMID30181729
PMCPMC6116076
OpenAlexW2888930410

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.