ArticleScientific reports2018
Functional development of olfactory tubercle domains during weaning period in mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Mapping Brain-Wide Neural Activity of Murine Attentional Processing in the Five-Choice Serial Reaction Time Task.Neuroscience bulletin · 2025Article
- Separation of pups from their mother mice enhances odor associative learning at the late lactation stage.Scientific reports · 2025Article
- Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life.Frontiers in neural circuits · 2024Review
- Synaptic plasticity and roles of orexin in distinct domains of the olfactory tubercle.Frontiers in neural circuits · 2024Article
- Distinct limbic dopamine regulation across olfactory-tubercle subregions through integration of in vivo fast-scan cyclic voltammetry and optogenetics.Journal of neurochemistry · 2022Article
- Cellular Profiles of Prodynorphin and Preproenkephalin mRNA-Expressing Neurons in the Anterior Olfactory Tubercle of Mice.Frontiers in neural circuits · 2022Article
- Hypothetical Roles of the Olfactory Tubercle in Odor-Guided Eating Behavior.Frontiers in neural circuits · 2020Review
- Effect of Maternal Obesity and Preconceptional Weight Loss on Male and Female Offspring Metabolism and Olfactory Performance in Mice.Nutrients · 2019Article
- Opposing Roles of Dopamine Receptor D1- and D2-Expressing Neurons in the Anteromedial Olfactory Tubercle in Acquisition of Place Preference in Mice.Frontiers in behavioral neuroscience · 2019Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammals shift their feeding habits from mother's milk to environmental foods postnatally. While this weaning process accompanies the acquisition of attractive behaviour toward environmental foods, the underlying neural mechanism for the acquisition is poorly understood. We previously found that adult mouse olfactory tubercle (OT), which belongs to the olfactory cortex and ventral striatum, has functional domains that represent odour-induced motivated behaviours, and that c-fos induction occurs mainly in the anteromedial domain of OT following learned odour-induced food seeking behaviour. To address the question whether the anteromedial OT domain is involved in the postnatal acquisition of food seeking behaviour, we examined OT development during weaning of mice. Whereas at postnatal day 15 (P15), all mice were attracted to lactating mothers, P21 mice were more attracted to familiar food pellets. Mapping of c-fos induction during food seeking and eating behaviours showed that while c-fos activation was observed across wide OT domains at P15, the preferential activation of c-fos in the anteromedial domain occurred at P21 and later ages. These results indicate that preferential c-fos activation in the anteromedial OT domain occurred concomitantly with the acquisition of attractive behaviour toward food, which suggests the importance of this domain in the weaning process.
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