ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Latent variable analysis of negative affect and its contributions to neural responses during shock anticipation.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Aversive perception in a threat context: Separate and independent neural activation.Biological psychology · 2020Trial
- Neuroticism/Negative Emotionality Is Associated with Increased Reactivity to Uncertain Threat in the Bed Nucleus of the Stria Terminalis, Not the Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuroticism/negative emotionality is associated with increased reactivity to uncertain threat in the bed nucleus of the stria terminalis, not the amygdala.bioRxiv : the preprint server for biology · 2024Article
- Neurofeedback-Augmented Mindfulness Training Elicits Distinct Responses in the Subregions of the Insular Cortex in Healthy Adolescents.Brain sciences · 2022Article
- Abnormal functional connectivity in psoriasis patients with depression is associated with their clinical symptoms.Frontiers in neuroscience · 2022Article
- Emotional Memory and Amygdala Activation.Frontiers in behavioral neuroscience · 2022Article
- BNST specific mGlu5 receptor knockdown regulates sex-dependent expression of negative affect produced by adolescent ethanol exposure and adult stress.Translational psychiatry · 2021Article
- Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach.Journal of psychiatry & neuroscience : JPN · 2021Article
- Assessing the role of the amygdala in fear of pain: Neural activation under threat of shock.Journal of affective disorders · 2020Article
- Adolescent alcohol exposure produces sex differences in negative affect-like behavior and group I mGluR BNST plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- The impact of threat of shock-induced anxiety on the neural substrates of memory encoding and retrieval.Social cognitive and affective neuroscience · 2019Article
- Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect.Brain sciences · 2019Review
- Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework.Progress in brain research · 2019Article
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7 authors.
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Abstract
Negative affect is considered an important factor in the etiology of depression and anxiety, and is highly related to pain. However, negative affect is not a unitary construct. To identify specific targets for treatment development, we aimed to derive latent variables of negative affect and test their unique contributions to affective processing during anticipation of unpredictable, painful shock. Eighty-three subjects (43 with depression and anxiety spectrum disorders and 40 healthy controls) completed self-report measures of negative valence and underwent neuroimaging while exploring computer-simulated contexts with and without the threat of a painful, but tolerable, shock. Principal component analysis (PCA) extracted distinct components of general negative affect (GNA) and pain-related negative affect (PNA). While elevated GNA and PNA were both indicative of depression and anxiety disorders, greater PNA was more strongly related to task-specific anxious reactivity during shock anticipation. GNA was associated with increased precuneus and middle frontal gyrus activity, whereas PNA was related to increased bilateral anterior insula activity. Anterior insula activity mediated the relationship between PNA and task-specific anxious reactivity. In conclusion, GNA and PNA have distinct neural signatures and uniquely contribute to anxious anticipation. PNA, via insula activity, may relate to arousal in ways that could contribute to affective dysregulation, and thus may be an important treatment target.
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