ArticleScientific reports2018
Microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-TNF treatment.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Catheter-assisted evacuation through limited laminectomy for traumatic long-segment spinal epidural hematoma in ankylosing spondylitis: a technical note and two case reports.BMC musculoskeletal disorders · 2026Article
- Retinal microvascular changes in patients with ankylosing spondylitis receiving biologic therapy: a cross-sectional OCTA study.BMC ophthalmology · 2026Article
- The Cardiovascular Safety of Tumour Necrosis Factor Inhibitors in Arthritic Conditions: A Structured Review with Recommendations.Rheumatology and therapy · 2025Review
- Comparison of Retinal Microvascular Changes in Axial Spondyloarthritis Using Optical Coherence Tomography Angiography: Anti-TNF vs. NSAID Therapy.Diagnostics (Basel, Switzerland) · 2025Article
- Abnormality detection in nailfold capillary images using deep learning with EfficientNet and cascade transfer learning.Scientific reports · 2025Article
- Coronary microvascular dysfunction in autoimmune rheumatic diseases: beyond coronary flow velocity reserve.Frontiers in cardiovascular medicine · 2024Review
- Fibroblast Insights into the Pathogenesis of Ankylosing Spondylitis.Journal of inflammation research · 2023Review
- The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases.Cell death discovery · 2022Review
- The second decade of anti-TNF-a therapy in clinical practice: new lessons and future directions in the COVID-19 era.Rheumatology international · 2022Review
- A brief human history of ankylosing spondylitis: A scoping review of pathogenesis, diagnosis, and treatment.Surgical neurology international · 2022Article
- Exploring the Diverse Immune and Genetic Landscape of Psoriatic Arthritis.Journal of clinical medicine · 2021Review
- Capillaroscopic Evidence of Microvascular Damage in Volleyball Players.International journal of environmental research and public health · 2021Article
- Determination of serum methylarginine levels by tandem mass spectrometric method in patients with ankylosing spondylitis.Amino acids · 2021Article
- Potential Role and Impact of Peripheral Blood Mononuclear Cells in Radiographic Axial Spondyloarthritis-Associated Endothelial Dysfunction.Diagnostics (Basel, Switzerland) · 2021Article
- Protective Effect of Nicorandil on Cardiac Microvascular Injury: Role of Mitochondrial Integrity.Oxidative medicine and cellular longevity · 2021Review
- Link Between Synovial and Myocardial Inflammation: Conceptual Framework to Explain the Pathogenesis of Heart Failure with Preserved Ejection Fraction in Patients with Systemic Rheumatic Diseases.Cardiac failure review · 2020Review
- The pathogenic role of coronary microvascular dysfunction in the setting of other cardiac or systemic conditions.Cardiovascular research · 2020Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Ankylosing spondylitis (AS) is associated with high cardiovascular morbidity and mortality. Recent studies indicate that microvascular dysfunction may underlie cardiovascular risk in AS. We hypothesized, that microvascular morphology and dysfunction is linked to AS activity and is modifiable by TNF-α inhibitor (TNFi) treatment. Functional Laser Doppler Flowmetry with post-occlusive reactive hyperemia, and structural nailfold capillaroscopy were performed in 54 patients with AS and 28 matched controls. Active AS was diagnosed based on BASDAI ≥ 4 (n = 37). Effects of 3-month TNFi on microcirculation in active AS were studied. AS was associated with prolonged time to peak hyperemia compared to healthy controls. High disease activity was associated with increased time to peak hyperemia and decreased peak hyperemia when compared to patients with inactive AS. In capillaroscopy, AS was associated with morphological abnormalities indicating increased neoangiogenesis and pericapillary edema compared to controls. Microvascular function improved following 3 months of TNFi in reference to basal flow as well as post-occlusive parameters. TNFi reduced pericapillary edema, while other parameters of capillary morphology remained unchanged. Microvascular dysfunction and capillary neovascular formation are associated with disease activity of AS. Anti-TNF-α treatment may restore microcirculation function and capillary edema but does not modify microvascular structural parameters.
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