ArticleScientific reports2018
Brain imaging reveals covert consciousness during behavioral unresponsiveness induced by propofol.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06400901 (Electrophysiology Based Brain Network Study on Deep Brain Nuclei LFP and Cortical EEG During the Recovery From General Anesthesia), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electrophysiology Based Brain Network Study on Deep Brain Nuclei LFP and Cortical EEG During the Recovery From General Anesthesia
Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Architectural reorganization of functional connectivity after propofol anesthesia exceeds within-state measurement variability and is only marginally reversed during early recovery.Neuroimage. Reports · 2026Article
- An open fMRI resource for studying human brain function and covert consciousness under anesthesia.Scientific data · 2026Article
- General anaesthesia decreases the uniqueness of brain functional connectivity across individuals and species.Nature human behaviour · 2025Article
- Distinct effects of global signal regression on brain activity during propofol and sevoflurane anesthesia.Frontiers in neuroscience · 2025Article
- A synergistic workspace for human consciousness revealed by Integrated Information Decomposition.eLife · 2024Article
- Increased task-relevant fMRI responsiveness in comatose cardiac arrest patients is associated with improved neurologic outcomes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- General anaesthesia reduces the uniqueness of brain connectivity across individuals and across species.bioRxiv : the preprint server for biology · 2023Article
- Distributed harmonic patterns of structure-function dependence orchestrate human consciousness.Communications biology · 2023Article
- Functional geometry of the cortex encodes dimensions of consciousness.Nature communications · 2023Article
- Editorial: Dissociations between neural activity and conscious state: a key to understanding consciousness.Frontiers in human neuroscience · 2023Article
- Neural complexity is a common denominator of human consciousness across diverse regimes of cortical dynamics.Communications biology · 2022Article
- Neural oscillations track recovery of consciousness in acute traumatic brain injury patients.Human brain mapping · 2022Article
- Informal Caregivers of Patients with Disorders of Consciousness: a Qualitative Study of Communication Experiences and Information Needs with Physicians.Neuroethics · 2022Article
- Augmenting Human Selves Through Artificial Agents - Lessons From the Brain.Frontiers in computational neuroscience · 2022Article
- Article
- Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane.Human brain mapping · 2021Article
- Article
- Foundations of Human Consciousness: Imaging the Twilight Zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Altered Global Brain Signal during Physiologic, Pharmacologic, and Pathologic States of Unconsciousness in Humans and Rats.Anesthesiology · 2020Article
- Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Detecting covert consciousness in behaviorally unresponsive patients by brain imaging is of great interest, but a reproducible model and evidence from independent sources is still lacking. Here we demonstrate the possibility of using general anesthetics in a within-subjects study design to test methods or statistical paradigms of assessing covert consciousness. Using noninvasive neuroimaging in healthy volunteers, we identified a healthy study participant who was able to exhibit the specific fMRI signatures of volitional mental imagery while behaviorally unresponsive due to sedation with propofol. Our findings reveal a novel model that may accelerate the development of new approaches to reproducibly detect covert consciousness, which is difficult to achieve in patients with heterogeneous and sometimes clinically unstable neuropathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.